About Fer-1-like protein 6
Fer-1-like protein 6 (FER1L6) is a protein
from Homo sapiens identified by UniProt accession
Q2WGJ9, 1857 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Fer-1-like protein 6 |
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| UniProt accession | Q2WGJ9 |
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| Gene | FER1L6 |
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| Organism | Homo sapiens |
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| Length | 1857 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.22
- genetic disorder · score 0.12
- Barrett's esophagus · score 0.06
- esophageal adenocarcinoma · score 0.03
- colorectal cancer · score 0.03
- colorectal adenocarcinoma · score 0.02
- adenocarcinoma · score 0.01
- myxosarcoma · score 0.01
- neoplasm · score 0.01
- pachyonychia congenita · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2WGJ9-F1 | alphafold | PREDICTED | 76.13 | — |
Amino-acid sequence (1857 residues)
MFGLKVKKKR NKAEKGLILA NKAAKDSQGD TEALQEEPSH QEGPRGDLVH DDASIFPVPS ASPKRRSKLL TKIHDGEVRS QNYQIAITIT EARQLVGENI DPVVTIEIGD EKKQSTVKEG TNSPFYNEYF VFDFIGPQVH LFDKIIKISV FHHKLIGSVL IGSFKVDLGT VYNQPGHQFC NKWALLTDPG DIRTGTKGYL KCDISVMGKG DVLKTSPKTS DTEEPIEKNL LIPNGFPLER PWARFYVRLY KAEGLPKMNS SIMANVTKAF VGDSKDLVDP FVEVSFAGQM GRTTVQKNCA DPVWHEQVIF KEMFPPLCRR VKIQVWDEGS MNDVALATHF IDLKKISNEQ DGDKGFLPTF GPAWINLYGS PRNHSLMDDY QEMNEGFGEG VSFRGRILVE IAVEILSGRA QESKFSKALK ELKLPSKDKD SKSSKGKDKA DKTEDGKSQQ ASNKTNSTEV EVESFDVPPE IVPEKNEEFL LFGAFFEATM IDRKIGDKPI SFEVSIGNFG NLIDGGSHHG SKKSAESAEE DLLPLLHEGQ GDVAHDVPIP MASTTHPEKP LVTEGNRNYN YLPFEAKKPC VYFISSWGDQ TFRLHWSNML EKMADFLEES IEEVRELIKI SQEAPEEKMK TVLSDFISRS SAFISEAEKK PKMLNQTTLD KKRLTLCWQE LEAMCKEAKG IIQQQKKKLS VDEMIHEAQN FVEKIRFLVD EPQHTIPDVF IWMLSNNRRV AYARIASKDL LYSPVAGQMG KHCGKIKTHF LKPPGKRPAG WSVQAKVDVY LWLGSIKHAS AILDNLPVGY EAEMSSKGAG TNHPPSNLLY QEQHVFQLRA HMYQARGLIA ADSNGLSDPF AKVTFLSHCQ TTKIISQTLS PTWNQMLLFN DLVLHGDVKE LAESPPLVVV ELYDSDAVGK PEYLGATVAA PVVKLADQDY EPPRLCYHPI FCGNLSGGDL LAVFELLQVP PSGLQGLPPV EPPDITQIYP VPANIRPVLS KYRVEVLFWG VREMKKVQLL SVDRPQALIE CGGQGVKSCV IQSYKNNPNF SIQADAFEVE LPENELLHPP LSICVVDWRA FGRSTLVGTY TINYLKQFLC KLREPLAPIT QVDGTQPGHD ISDSLTATES SGAHSSSQDP PADHIYVDVE PPPTVVPDSA QAQPAILVDV PDSSPMLEPE HTPVAQEPPK DGKPKDPRKP SRRSTKRRKR TIADESAENV IDWWSKYYAS LKKAQKAKER NPKGKKGNTE AKPDEVVVDI EDGPKKKKDK MLKKKPKDDG IPNLAILQIY DGDLESEFNN FEDWVKTFEL FRGKSTEDDH GLDGDRVIGK FKGSFCIYKS PQDSSSEDSG QLRIQQGIPP NHPVTVLIRV YIVAAFNLSP ADPDGKSDPY IVIKLGKTEI KDRDKYIPKQ LNPVFGRSFE IQATFPKESL LSILIYDHDM IGTDDLIGET KIDLENRFYS KHRAICGLQS QYEIEGYNAW RDTSKPTEIL TKLCKDNKLD GPYFHPGKIQ IGNQVFSGKT IFTEEDTDET VESYEHLALK VLHSWEDIPE VGCRLVPEHI ETRPLYHKDK PGMEQGRLQM WVDMFPKDMP QPGPPVDISP RRPKGYELRV TIWNTEDVIL EDENIFTGQK SSDIYVKGWL KGLEDDKQET DVHYNSLTGE GNFNWRFLFP FQYLPAEKQM VITKRENIFS LEKMECKTPA VLVLQVWDFE RLSSDDFLGT LEMNLNSFPR AAKSAKACDL AKFENASEET KISIFQQKRV RGWWPFSKSK ELTGKVEAEF HLVTAEEAEK NPVGKARKEP EPLAKPNRPD TSFSWFMSPF KCLYYLIWKN YKKYIIIAFI LIILIIFLVL FIYTLPGAIS RRIVVGS
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