About GRB2-associated-binding protein 4
GRB2-associated-binding protein 4 (GAB4) is a protein
from Homo sapiens identified by UniProt accession
Q2WGN9, 574 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | GRB2-associated-binding protein 4 |
|---|
| UniProt accession | Q2WGN9 |
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| Gene | GAB4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 574 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (13)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.27
- PHF-tau measurement · score 0.26
- blood protein measurement · score 0.24
- interleukin 17 receptor A measurement · score 0.09
- drug use measurement · score 0.07
- monocyte percentage of leukocytes · score 0.06
- neutrophil count · score 0.03
- leukocyte count · score 0.03
- metabolite measurement · score 0.03
- breast carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q2WGN9-F1 | alphafold | PREDICTED | 53.35 | — |
Amino-acid sequence (574 residues)
MSLPSPSPSR ELCPPDPAFA PLSSWPGSGP AGGSTRSGHV LYSGWLRKSP PEKKLRLFAW RKRWFILRRG QTSSDPDVLE YYKNDGSKKP LRTINLNLCE QLDVDVTLNF NKKEIQKGYM FDIKTSERTF YLVAETREDM NEWVQSICQI CGFRQEESTG FLGNISSASH GLCSSPAEPS CSHQHLPQEQ EPTSEPPVSH CVPPTWPIPA PPGCLRSHQH ASQRAEHARS ASFSQGSEAP FIMRRNTAMQ NLAQHSGYSV DGVSGHIHGF HSLSKPSQHN AEFRGSTHRI PWSLASHGHT RGSLTGSEAD NEASSGKYTQ HGGGNASRPA ESMHEGVCSF LPGRTLVGLS DSIASEGSCV PMNPGSPTLP AVKQAGDDSQ GVCIPVGSCL VRFDLLGSPL TELSMHQDLS QGHEVQLPPV NRSLKPNQKA NPTPPNLRNN RVINELSFKP PVTEPWSGTS HTFDSSSSQH PISTQSITNT DSEDSGERYL FPNPASAFPV SGGTSSSAPP RSTGNIHYAA LDFQPSKPSI GSVTSGKKVD YVQVDLEKTQ ALQKTMHEQM CLRQSSEPPR GAKL
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