About Leucine-rich repeat flightless-interacting protein 1
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) is a protein
from Homo sapiens identified by UniProt accession
Q32MZ4, 808 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Leucine-rich repeat flightless-interacting protein 1 |
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| UniProt accession | Q32MZ4 |
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| Gene | LRRFIP1 |
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| Organism | Homo sapiens |
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| Length | 808 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (90)
Diseases linked to this target (Open Targets).
- cancer · score 0.58
- myelodysplastic syndrome · score 0.37
- chronic myelogenous leukemia · score 0.37
- leukemia · score 0.37
- acute lymphoblastic leukemia · score 0.37
- neurodegenerative disease · score 0.36
- mean platelet volume · score 0.36
- endometrial cancer · score 0.28
- breast adenocarcinoma · score 0.27
- PHF-tau measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q32MZ4-F1 | alphafold | PREDICTED | 54.99 | — |
Amino-acid sequence (808 residues)
MTSPAAAQSR EIDCLSPEAQ KLAEARLAAK RAARAEAREI RMKELERQQK EEDSERYSRR SRRNTSASDE DERMSVGSRG SLRVEERPEK DFTEKGSRNM PGLSAATLAS LGGTSSRRGS GDTSISIDTE ASIREIKELN ELKDQIQDVE GKYMQGLKEM KDSLAEVEEK YKKAMVSNAQ LDNEKTNFMY QVDTLKDMLL ELEEQLAESR RQYEEKNKEF EREKHAHSIL QFQFAEVKEA LKQREEMLEK HGIILNSEIA TNGETSDTLN NVGYQGPTKM TKEELNALKS TGDGTLGRAS EVEVKNEIVA NVGKREILHN TEKEQHTEDT VKDCVDIEVF PAGENTEDQK SSEDTAPFLG TLAGATYEEQ VQSQILESSS LPENTVQVES NEVMGAPDDR TRTPLEPSNC WSDLDGGNHT ENVGEAAVTQ VEEQAGTVAS CPLGHSDDTV YHDDKCMVEV PQELETSTGH SLEKEFTNQE AAEPKEVPAH STEVGRDHNE EEGEETGLRD EKPIKTEVPG SPAGTEGNCQ EATGPSTVDT QNEPLDMKEP DEEKSDQQGE ALDSSQKKTK NKKKKNKKKK SPVPVETLKD VKKELTYQNT DLSEIKEEEQ VKSTDRKSAV EAQNEVTENP KQKIAAESSE NVDCPENPKI KLDGKLDQEG DDVQTAAEEV LADGDTLDFE DDTVQSSGPR AGGEELDEGV AKDNAKIDGA TQSSPAEPKS EDADRCTLPE HESPSQDISD ACEAESTERC EMSEHPSQTV RKALDSNSLE NDDLSAPGRE PGHFNPESRE DTRGGNEKGK SKEDCTMS
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