About Prospero homeobox protein 2
Prospero homeobox protein 2 (PROX2) is a protein
from Homo sapiens identified by UniProt accession
Q3B8N5, 592 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Prospero homeobox protein 2 |
|---|
| UniProt accession | Q3B8N5 |
|---|
| Gene | PROX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 592 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- neuroticism measurement · score 0.24
- Parkinson disease · score 0.20
- monocyte count · score 0.19
- lysosomal storage disease · score 0.18
- Alzheimer disease · score 0.18
- multiple sclerosis · score 0.18
- high density lipoprotein cholesterol measurement · score 0.18
- Red cell distribution width · score 0.13
- FEV/FVC ratio · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3B8N5-F1 | alphafold | PREDICTED | 59.85 | — |
Amino-acid sequence (592 residues)
MDPNSILLSP QPQICSHLAE ACTEGERSSS PPELDRDSPF PWSQVPSSSP TDPEWFGDEH IQAKRARVET IVRGMCLSPN PLVPGNAQAG VSPRCPKKAR ERKRKQNLPT PQGLLMPAPA WDQGNRKGGP RVREQLHLLK QQLRHLQEHI LQAAKPRDTA QGPGGCGTGK GPLSAKQGNG CGPRPWVVDG DHQQGTSKDL SGAEKHQESE KPSFLPSGAP ASLEILRKEL TRAVSQAVDS VLQKVLLDPP GHLTQLGRSF QGQVAEGRSE PSPPVGGACK DPLALAALPR RVQLQAGVPV GNLSLAKRLD SPRYPIPPRM TPKPCQDPPA NFPLTAPSHI QENQILSQLL GHRYNNGHWS SSPPQDSSSQ RHPSSEPALR PWRTTKPQPL VLSQQQCPLP FTSAHLESLP LLPSVKMEQR GLHAVMEALP FSLLHIQEGL NPGHLKKAKL MFFFTRYPSS NLLKVYFPDV QFNRCITSQM IKWFSNFREF YYIQMEKSAR QAISDGVTNP KMLVVLRNSE LFQALNMHYN KGNDFEVPDC FLEIASLTLQ EFFRAVSAGR DSDPSWKKPI YKIISKLDSD IPEIFKSSSY PQ
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