Sperm-egg fusion protein TMEM95 (TMEM95)

About Sperm-egg fusion protein TMEM95

Sperm-egg fusion protein TMEM95 (TMEM95) is a protein from Homo sapiens identified by UniProt accession Q3KNT9, 176 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Sperm-egg fusion protein TMEM95
UniProt accession	Q3KNT9
Gene	TMEM95
Organism	Homo sapiens
Length	176 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
Rare genetic female infertility · score 0.09
Female infertility due to fertilization defect · score 0.08
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.08
male infertility with teratozoospermia due to single gene mutation · score 0.08
partial chromosome Y deletion · score 0.08
female infertility due to oocyte meiotic arrest · score 0.07
spermatogenic failure 3 · score 0.07
spermatogenic failure 55 · score 0.07
spermatogenic failure 53 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q3KNT9-F1	alphafold	PREDICTED	81.70	—

Amino-acid sequence (176 residues)

MWRLALGGVF LAAAQACVFC RLPAHDLSGR LARLCSQMEA RQKECGASPD FSAFALDEVS MNKVTEKTHR VLRVMEIKEA VSSLPSYWSW LRKTKLPEYT REALCPPACR GSTTLYNCST CKGTEVSCWP RKRCFPGSQD LWEAKILLLS IFGAFLLLGV LSLLVESHHL QAKSGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards