About Polycomb group RING finger protein 3
Polycomb group RING finger protein 3 (PCGF3) is a protein
from Homo sapiens identified by UniProt accession
Q3KNV8, 242 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | Polycomb group RING finger protein 3 |
|---|
| UniProt accession | Q3KNV8 |
|---|
| Gene | PCGF3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 242 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (116)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.37
- neurodegenerative disease · score 0.37
- neutrophil count · score 0.37
- leukocyte count · score 0.34
- myeloid white cell count · score 0.33
- mathematical ability · score 0.29
- intelligence · score 0.28
- monocyte percentage of leukocytes · score 0.28
- HbA1c measurement · score 0.28
- diabetes mellitus · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3KNV8-F1 | alphafold | PREDICTED | 85.27 | — |
Amino-acid sequence (242 residues)
MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GMEVPGDIKG ETCSAKQHLD SHRNGETKAD DSSNKEAAEE KPEEDNDYHR SDEQVSICLE CNSSKLRGLK RKWIRCSAQA TVLHLKKFIA KKLNLSSFNE LDILCNEEIL GKDHTLKFVV VTRWRFKKAP LLLHYRPKMD LL
Explore Polycomb group RING finger protein 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets