About Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 (ITPRIPL2) is a protein
from Homo sapiens identified by UniProt accession
Q3MIP1, 535 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 |
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| UniProt accession | Q3MIP1 |
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| Gene | ITPRIPL2 |
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| Organism | Homo sapiens |
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| Length | 535 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- diastolic blood pressure · score 0.27
- PHF-tau measurement · score 0.26
- body height · score 0.05
- self reported educational attainment · score 0.04
- diet measurement · score 0.03
- Red cell distribution width · score 0.03
- sitting height measurement · score 0.03
- juvenile dermatomyositis · score 0.01
- hepatocellular carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3MIP1-F1 | alphafold | PREDICTED | 79.19 | — |
Amino-acid sequence (535 residues)
MSVHYTLNLR VFWPLVTGLC TALVCLYHVL RGSGGARAEP ADGVDGGFPL LKVAVLLLLS YVLLRCRHAV RQRFLPGSPR LEGHAAFSSR HFREPGLSIL LESYYEHEVR LSPHVLGHSK AHVSRIVGEL VRAGRARGSP GLIPGGALAL AFRGDFIQVG SAYEQHKIRR PDSFDVLVPL RLPPLVALEP RSLGEEPALA PAFRGCFLCA LKAPPSPSGA SGGHWLRDCK PFADAFCVDV RGRRHLSATL VLRWFQSHLQ RSLATVRYSL EGRCRVTLTP GGLEQPPTLH ILPCRTDYGC CRLSMAVRLI PAVHLGDGVF LVAPPPPPLP SAPLLELPEG LRAEALWGVN TARQEQKLLS WLQERAAPGA CYLKCLQLLK ALRDLGARGL DSAAATQWGR ILSSYVLKTV LLAVLLRKGA PGQGWDEEHL GRCLEELVQF LRDCLLRRHT LFHCVLGPGG AAAEVGPLPK ALREAAPVDL LAAFDGHARE LAAARLLSTW QRLPQLLRAY GGPRYLARCP PPRSQRTQGF LEGEP
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