About Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B (MGAT5B) is a protein
from Homo sapiens identified by UniProt accession
Q3V5L5, 792 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B |
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| UniProt accession | Q3V5L5 |
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| Gene | MGAT5B |
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| Organism | Homo sapiens |
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| Length | 792 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.31
- emphysema · score 0.17
- total cholesterol measurement · score 0.06
- eye disease · score 0.04
- Herpetic encephalitis · score 0.04
- severe combined immunodeficiency due to CTPS1 deficiency · score 0.04
- Autosomal dominant intermediate Charcot-Marie-Tooth disease type B · score 0.04
- immunodeficiency 18 · score 0.04
- agammaglobulinemia 10, autosomal dominant · score 0.04
- immunodeficiency 62 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3V5L5-F1 | alphafold | PREDICTED | 82.00 | — |
Amino-acid sequence (792 residues)
MITVNPDGKI MVRRCLVTLR PFRLFVLGIG FFTLCFLMTS LGGQFSARRL GDSPFTIRTE VMGGPESRGV LRKMSDLLEL MVKRMDALAR LENSSELHRA GGDLHFPADR MPPGAGLMER IQAIAQNVSD IAVKVDQILR HSLLLHSKVS EGRRDQCEAP SDPKFPDCSG KVEWMRARWT SDPCYAFFGV DGTECSFLIY LSEVEWFCPP LPWRNQTAAQ RAPKPLPKVQ AVFRSNLSHL LDLMGSGKES LIFMKKRTKR LTAQWALAAQ RLAQKLGATQ RDQKQILVHI GFLTEESGDV FSPRVLKGGP LGEMVQWADI LTALYVLGHG LRVTVSLKEL QSNLGVPPGR GSCPLTMPLP FDLIYTDYHG LQQMKRHMGL SFKKYRCRIR VIDTFGTEPA YNHEEYATLH GYRTNWGYWN LNPKQFMTMF PHTPDNSFMG FVSEELNETE KRLIKGGKAS NMAVVYGKEA SIWKLQGKEK FLGILNKYME IHGTVYYESQ RPPEVPAFVK NHGLLPQPEF QQLLRKAKLF IGFGFPYEGP APLEAIANGC IFLQSRFSPP HSSLNHEFFR GKPTSREVFS QHPYAENFIG KPHVWTVDYN NSEEFEAAIK AIMRTQVDPY LPYEYTCEGM LERIHAYIQH QDFCRAPDPA LPEAHAPQSP FVLAPNATHL EWARNTSLAP GAWPPAHALR AWLAVPGRAC TDTCLDHGLI CEPSFFPFLN SQDAFLKLQV PCDSTESEMN HLYPAFAQPG QECYLQKEPL LFSCAGSNTK YRRLCPCRDF RKGQVALCQG CL
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