About Transmembrane protein 176B
Transmembrane protein 176B (TMEM176B) is a protein
from Homo sapiens identified by UniProt accession
Q3YBM2, 270 residues long.
MolForge cross-references it against 0 known binders and
282 disease associations.
Target properties
| Protein name | Transmembrane protein 176B |
|---|
| UniProt accession | Q3YBM2 |
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| Gene | TMEM176B |
|---|
| Organism | Homo sapiens |
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| Length | 270 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (282)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.33
- appendicular lean mass · score 0.29
- hemoglobin measurement · score 0.25
- testosterone measurement · score 0.23
- calcium measurement · score 0.22
- serum albumin measurement · score 0.21
- blood protein measurement · score 0.21
- hematocrit · score 0.21
- type 2 diabetes mellitus · score 0.20
- alkaline phosphatase measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q3YBM2-F1 | alphafold | PREDICTED | 70.30 | — |
Amino-acid sequence (270 residues)
MTQNTVIVNG VAMASRPSQP THVNVHIHQE SALTQLLKAG GSLKKFLFHP GDTVPSTARI GYEQLALGVT QILLGVVSCV LGVCLSLGPW TVLSASGCAF WAGSVVIAAG AGAIVHEKHP GKLAGYISSL LTLAGFATAM AAVVLCVNSF IWQTEPFLYI DTVCDRSDPV FPTTGYRWMR RSQENQWQKE ECRAYMQMLR KLFTAIRALF LAVCVLKVIV SLVSLGVGLR NLCGQSSQPL NEEGSEKRLL GENSVPPSPS REQTSTAIVL
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