About Protein mono-ADP-ribosyltransferase PARP15
Protein mono-ADP-ribosyltransferase PARP15 (PARP15) is a protein
from Homo sapiens identified by UniProt accession
Q460N3, 678 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Protein mono-ADP-ribosyltransferase PARP15 |
|---|
| UniProt accession | Q460N3 |
|---|
| Gene | PARP15 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 678 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (38)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.26
- neurodegenerative disease · score 0.15
- protein measurement · score 0.08
- acoustic startle blink response measurement · score 0.05
- HbA1c measurement · score 0.02
- Sepsis · score 0.02
- apolipoprotein B measurement · score 0.02
- acute myeloid leukemia · score 0.02
- cancer · score 0.01
- central nervous system cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q460N3-F1 | alphafold | PREDICTED | 79.08 | — |
Amino-acid sequence (678 residues)
MAAPGPLPAA ALSPGAPTPR ELMHGVAGVT SRAGRDREAG SVLPAGNRGA RKASRRSSSR SMSRDNKFSK KDCLSIRNVV ASIQTKEGLN LKLISGDVLY IWADVIVNSV PMNLQLGGGP LSRAFLQKAG PMLQKELDDR RRETEEKVGN IFMTSGCNLD CKAVLHAVAP YWNNGAETSW QIMANIIKKC LTTVEVLSFS SITFPMIGTG SLQFPKAVFA KLILSEVFEY SSSTRPITSP LQEVHFLVYT NDDEGCQAFL DEFTNWSRIN PNKARIPMAG DTQGVVGTVS KPCFTAYEMK IGAITFQVAT GDIATEQVDV IVNSTARTFN RKSGVSRAIL EGAGQAVESE CAVLAAQPHR DFIITPGGCL KCKIIIHVPG GKDVRKTVTS VLEECEQRKY TSVSLPAIGT GNAGKNPITV ADNIIDAIVD FSSQHSTPSL KTVKVVIFQP ELLNIFYDSM KKRDLSASLN FQSTFSMTTC NLPEHWTDMN HQLFCMVQLE PGQSEYNTIK DKFTRTCSSY AIEKIERIQN AFLWQSYQVK KRQMDIKNDH KNNERLLFHG TDADSVPYVN QHGFNRSCAG KNAVSYGKGT YFAVDASYSA KDTYSKPDSN GRKHMYVVRV LTGVFTKGRA GLVTPPPKNP HNPTDLFDSV TNNTRSPKLF VVFFDNQAYP EYLITFTA
Explore Protein mono-ADP-ribosyltransferase PARP15 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets