About Synaptic vesicle glycoprotein 2C
Synaptic vesicle glycoprotein 2C (SV2C) is a protein
from Homo sapiens identified by UniProt accession
Q496J9, 727 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | Synaptic vesicle glycoprotein 2C |
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| UniProt accession | Q496J9 |
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| Gene | SV2C |
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| Organism | Homo sapiens |
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| Length | 727 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (66)
Diseases linked to this target (Open Targets).
- botulism · score 0.57
- mean corpuscular volume · score 0.42
- Red cell distribution width · score 0.40
- monocyte count · score 0.36
- platelet count · score 0.34
- PHF-tau measurement · score 0.33
- cumulative dose response to bevacizumab · score 0.33
- gut microbiome measurement · score 0.32
- platelet component distribution width · score 0.32
- reticulocyte count · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q496J9-F1 | alphafold | PREDICTED | 77.97 | — |
Amino-acid sequence (727 residues)
MEDSYKDRTS LMKGAKDIAR EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ DEEDDDDYYP AGETYNGEAN DDEGSSEATE GHDEDDEIYE GEYQGIPSMN QAKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLFCRLL SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG TWYRRCFVRI RTELYGIWLT FMRCFNYPVR DNTIKLTIVW FTLSFGYYGL SVWFPDVIKP LQSDEYALLT RNVERDKYAN FTINFTMENQ IHTGMEYDNG RFIGVKFKSV TFKDSVFKSC TFEDVTSVNT YFKNCTFIDT VFDNTDFEPY KFIDSEFKNC SFFHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKSIP ILLASTVLVC GGLVGLCLPD TRTQVLM
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