Cytokine-like nuclear factor N-PAC (GLYR1)

About Cytokine-like nuclear factor N-PAC

Cytokine-like nuclear factor N-PAC (GLYR1) is a protein from Homo sapiens identified by UniProt accession Q49A26, 553 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	Cytokine-like nuclear factor N-PAC
UniProt accession	Q49A26
Gene	GLYR1
Organism	Homo sapiens
Length	553 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
body height · score 0.14
inflammatory bowel disease · score 0.11
mean platelet volume · score 0.10
lean body mass · score 0.09
fat body mass · score 0.08
C-reactive protein measurement · score 0.07
neoplasm · score 0.07
whole body water mass · score 0.07
systolic blood pressure · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q49A26-F1	alphafold	PREDICTED	77.88	—

Amino-acid sequence (553 residues)

MAAVSLRLGD LVWGKLGRYP PWPGKIVNPP KDLKKPRGKK CFFVKFFGTE DHAWIKVEQL KPYHAHKEEM IKINKGKRFQ QAVDAVEEFL RRAKGKDQTS SHNSSDDKNR RNSSEERSRP NSGDEKRKLS LSEGKVKKNM GEGKKRVSSG SSERGSKSPL KRAQEQSPRK RGRPPKDEKD LTIPESSTVK GMMAGPMAAF KWQPTASEPV KDADPHFHHF LLSQTEKPAV CYQAITKKLK ICEEETGSTS IQAADSTAVN GSITPTDKKI GFLGLGLMGS GIVSNLLKMG HTVTVWNRTA EKCDLFIQEG ARLGRTPAEV VSTCDITFAC VSDPKAAKDL VLGPSGVLQG IRPGKCYVDM STVDADTVTE LAQVIVSRGG RFLEAPVSGN QQLSNDGMLV ILAAGDRGLY EDCSSCFQAM GKTSFFLGEV GNAAKMMLIV NMVQGSFMAT IAEGLTLAQV TGQSQQTLLD ILNQGQLASI FLDQKCQNIL QGNFKPDFYL KYIQKDLRLA IALGDAVNHP TPMAAAANEV YKRAKALDQS DNDMSAVYRA YIH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards