Dual specificity phosphatase 28 (DUSP28)

About Dual specificity phosphatase 28

Dual specificity phosphatase 28 (DUSP28) is a protein from Homo sapiens identified by UniProt accession Q4G0W2, 176 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	Dual specificity phosphatase 28
UniProt accession	Q4G0W2
Gene	DUSP28
Organism	Homo sapiens
Length	176 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
mean corpuscular hemoglobin · score 0.16
hemolytic anemia · score 0.06
neoplasm · score 0.05
cancer · score 0.05
mean platelet volume · score 0.03
hair shape measurement · score 0.02
hepatocellular carcinoma · score 0.02
metastatic melanoma · score 0.01
IGA glomerulonephritis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q4G0W2-F1	alphafold	PREDICTED	90.15	—

Amino-acid sequence (176 residues)

MGPAEAGRRG AASPVPPPLV RVAPSLFLGS ARAAGAEEQL ARAGVTLCVN VSRQQPGPRA PGVAELRVPV FDDPAEDLLA HLEPTCAAME AAVRAGGACL VYCKNGRSRS AAVCTAYLMR HRGLSLAKAF QMVKSARPVA EPNPGFWSQL QKYEEALQAQ SCLQGEPPAL GLGPEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards