About Probable cation-transporting ATPase 13A5
Probable cation-transporting ATPase 13A5 (ATP13A5) is a protein
from Homo sapiens identified by UniProt accession
Q4VNC0, 1218 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Probable cation-transporting ATPase 13A5 |
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| UniProt accession | Q4VNC0 |
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| Gene | ATP13A5 |
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| Organism | Homo sapiens |
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| Length | 1218 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- Hodgkins lymphoma · score 0.28
- salivary metabolite measurement · score 0.28
- creatinine measurement · score 0.28
- breast adenocarcinoma · score 0.10
- linear and whorled nevoid hypermelanosis · score 0.05
- chronic myeloproliferative disorder · score 0.05
- eosinophil peroxidase deficiency · score 0.04
- neutropenia, severe congenital, 1, autosomal dominant · score 0.04
- ichthyosis prematurity syndrome · score 0.04
- chronic myelogenous leukemia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4VNC0-F1 | alphafold | PREDICTED | 78.78 | — |
Amino-acid sequence (1218 residues)
MEENSKKDHR ALLNQGEEDE LEVFGYRDHN VRKAFCLVAS VLTCGGLLLV FYWRPQWRVW ANCIPCPLQE ADTVLLRTTD EFQRYMRKKV FCLYLSTLKF PVSKKWEESL VADRHSVINQ ALIKPELKLR CMEVQKIRYV WNDLEKRFQK VGLLEDSNSC SDIHQTFGLG LTSEEQEVRR LVCGPNAIEV EIQPIWKLLV KQVLNPFYVF QAFTLTLWLS QGYIEYSVAI IILTVISIVL SVYDLRQQSV KLHNLVEDHN KVQVTIIVKD KGLEELESRL LVPGDILILP GKFSLPCDAV LIDGSCVVNE GMLTGESIPV TKTPLPQMEN TMPWKCHSLE DYRKHVLFCG TEVIQVKPSG QGPVRAVVLQ TGYNTAKGDL VRSILYPRPL NFKLYSDAFK FIVFLACLGV MGFFYALGVY MYHGVPPKDT VTMALILLTV TVPPVLPAAL TIGNVYAQKR LKKKKIFCIS PQRINMCGQI NLVCFDKTGT LTEDGLDLWG TVPTADNCFQ EAHSFASGQA VPWSPLCAAM ASCHSLILLN GTIQGDPLDL KMFEGTAWKM EDCIVDSCKF GTSVSNIIKP GPKASKSPVE AIITLCQFPF SSSLQRMSVI AQLAGENHFH VYMKGAPEMV ARFCRSETVP KNFPQELRSY TVQGFRVIAL AHKTLKMGNL SEVEHLAREK VESELTFLGL LIMENRLKKE TKLVLKELSE ARIRTVMITG DNLQTAITVA KNSEMIPPGS QVIIVEADEP EEFVPASVTW QLVENQETGP GKKEIYMHTG NSSTPRGEGG SCYHFAMSGK SYQVIFQHFN SLLPKILVNG TVFARMSPGQ KSSLIEEFQK LNYYVGMCGD GANDCGALKA AHAGISLSEQ EASVASPFTS KTTNIQCVPH LIREGRAALV SSFGVFKYLT MYGIIQFISA LLLYWQLQLF GNYQYLMQDV AITLMVCLTM SSTHAYPKLA PYRPAGQLLS PPLLLSIFLN SCFSCIVQIS AFLYVKQQPW YCEVYQYSEC FLANQSNFST NVSLERNWTG NATLIPGSIL SFETTTLWPI TTINYITVAF IFSKGKPFRK PIYTNYIFSF LLLAALGLTI FILFSDFQVI YRGMELIPTI TSWRVLILVV ALTQFCVAFF VEDSILQNHE LWLLIKREFG FYSKSQYRTW QKKLAEDSTW PPINRTDYSG DGKNGFYING GYESHEQIPK RKLKLGGQPT EQHFWARL
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