About Membralin
Membralin (TMEM259) is a protein
from Homo sapiens identified by UniProt accession
Q4ZIN3, 620 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Membralin |
|---|
| UniProt accession | Q4ZIN3 |
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| Gene | TMEM259 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 620 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (41)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.34
- neurodegenerative disease · score 0.28
- monocyte count · score 0.25
- body height · score 0.24
- eosinophil percentage of leukocytes · score 0.17
- red blood cell density measurement · score 0.15
- eosinophil count · score 0.12
- mean corpuscular volume · score 0.09
- leukocyte count · score 0.09
- eosinophil percentage of granulocytes · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q4ZIN3-F1 | alphafold | PREDICTED | 63.37 | — |
Amino-acid sequence (620 residues)
MSEHVEPAAP GPGPNGGGGG PAPARGPRTP NLNPNPLINV RDRLFHALFF KMAVTYSRLF PPAFRRLFEF FVLLKALFVL FVLAYIHIVF SRSPINCLEH VRDKWPREGI LRVEVRHNSS RAPVFLQFCD SGGRGSFPGL AVEPGSNLDM EDEEEEELTM EMFGNSSIKF ELDIEPKVFK PPSSTEALND SQEFPFPETP TKVWPQDEYI VEYSLEYGFL RLSQATRQRL SIPVMVVTLD PTRDQCFGDR FSRLLLDEFL GYDDILMSSV KGLAENEENK GFLRNVVSGE HYRFVSMWMA RTSYLAAFAI MVIFTLSVSM LLRYSHHQIF VFIVDLLQML EMNMAIAFPA APLLTVILAL VGMEAIMSEF FNDTTTAFYI ILIVWLADQY DAICCHTSTS KRHWLRFFYL YHFAFYAYHY RFNGQYSSLA LVTSWLFIQH SMIYFFHHYE LPAILQQVRI QEMLLQAPPL GPGTPTALPD DMNNNSGAPA TAPDSAGQPP ALGPVSPGAS GSPGPVAAAP SSLVAAAASV AAAAGGDLGW MAETAAIITD ASFLSGLSAS LLERRPASPL GPAGGLPHAP QDSVPPSDSA ASDTTPLGAA VGGPSPASMA PTEAPSEVGS
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