About von Willebrand factor A domain-containing protein 3B
von Willebrand factor A domain-containing protein 3B (VWA3B) is a protein
from Homo sapiens identified by UniProt accession
Q502W6, 1294 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | von Willebrand factor A domain-containing protein 3B |
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| UniProt accession | Q502W6 |
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| Gene | VWA3B |
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| Organism | Homo sapiens |
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| Length | 1294 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- Adult-onset autosomal recessive cerebellar ataxia · score 0.58
- triglyceride measurement · score 0.28
- urate measurement · score 0.28
- bone density · score 0.28
- self reported educational attainment · score 0.21
- blood protein measurement · score 0.09
- hypertension · score 0.05
- Barrett's esophagus · score 0.03
- neutrophil percentage of leukocytes · score 0.03
- sarcoidosis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q502W6-F1 | alphafold | PREDICTED | 68.66 | — |
Amino-acid sequence (1294 residues)
MEKSGPSSTI SEQQLQRQEG WINTKTDLAE QSLISSEKWL QLHGLKSNKL TLKQILSQIG FPHCEDYVAS LGRPVASRYA DGLFPQLYRA EDGRVYNLTA KSELIYQFVE HLTQAVESYK QRMDWLTSKS RQIFGVILEQ CVTIVLDFGG ILEGELDLCR EALTMVLQEQ VAHITEFNII RVSQEPVKWQ ENATPVTEQS IATAISWVEK LTVELTVSEA GRLDALLEAG RDKTIESIYY FVVGDVPEES KELLLQRALE IPCPVYTVSF NARGEGTIAF LKDLSAKTHS RFHAFAERTE CVEFPAFSTK DGDNVMTWNS RKLKGKLPPG AGVREDVFLV WQEMEEACST LAQIQRLVAE PPKPDVATVD CESETTSVEI ASNPEDTWDS KTWLQKYGLK AQKLSLYDVL ADCSFRHADG VVDIKAKPEN ESVQTSAETN KKTVHAKYCS RFVHAPWKDG SLVHVNITKE KCKWYSERIH TALARIRRRI KWLQDGSQSL FGRLHNDCIY ILIDTSHSMK SKLDLVKDKI IQFIQEQLKY KSKFNFVKFD GQAVAWREQL AEVNEDNLEQ AQSWIRDIKI GSSTNTLSAL KTAFADKETQ AIYLLTDGRP DQPPETVIDQ VKRFQEIPIY TISFNYNDEI ANRFLKEVAA LTGGEFHFYN FGCKDPTPPE AVQNEDLTLL VKEMEQGHSD LEKMQDLYSE SLIMDWWYNA EKDGDSKHQK EICSMISTPE KCAKPQSDVD STQTSSLNML KGPWGLSDQK VQKKKVLHAE STKTSLLRSQ MSSLRSSACS ERKDGLSNAS SRRTALSDKE MSILLAEEWL DDKSSEKVTR EGSQVYDHDS SDVSSENWLK TYGLVAKKLT LMDALSVAAV PHSSTYVPVL DKHVVSKVFD EVFPLAHVCN DTNKMTLINP QGAKLNIYKR KVEQAIQSYE KRLNKIVWRA LSQEEKEKLD ANKPIQYLEN KTVLNQALER LNWPISLKEL SMLESEILAG KMYIQQAMEL QEAAKKNYAN KAPGEQQKLQ GNPTKKTKSK RPDPLKGQKV IARCDENGFY FPGVVKKCVS RTQALVGFSY GDTKVVSTSF ITPVGGAMPC PLLQVGDYVF AKIVIPKGFD FYVPAIVIAL PNKHVATEKF YTVLKCNNRR EFCPRSALIK ISQNKYALSC SHIKSPPIPE DPEVEDVEAR NSAFLFWPLK EADTQDSREP RREKPRRKKR PAKQPLQQAA PSDSDGSSHG ISSHGSCQGT HPEPRTAHLH FPAAGRLGLS SHAIIATPPP RAALPCTLQA THSSKGLRSV PETL
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