Novel acetylcholine receptor chaperone (TMEM35A)

About Novel acetylcholine receptor chaperone

Novel acetylcholine receptor chaperone (TMEM35A) is a protein from Homo sapiens identified by UniProt accession Q53FP2, 167 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Novel acetylcholine receptor chaperone
UniProt accession	Q53FP2
Gene	TMEM35A
Organism	Homo sapiens
Length	167 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

obstructive sleep apnea · score 0.07
Potocki-Lupski syndrome · score 0.04
attention deficit hyperactivity disorder · score 0.04
ichthyosis-hepatosplenomegaly-cerebellar degeneration syndrome · score 0.04
ACTH-independent macronodular adrenal hyperplasia 1 · score 0.03
primary pigmented nodular adrenocortical disease · score 0.03
pigmented nodular adrenocortical disease, primary, 1 · score 0.03
colorectal cancer · score 0.03
glioblastoma multiforme · score 0.02
colorectal adenocarcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53FP2-F1	alphafold	PREDICTED	81.53	—

Amino-acid sequence (167 residues)

MASPRTVTIV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKPLPGNAE EQPSLYEKAP QGKVKVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards