ORM1-like protein 2 (ORMDL2)

About ORM1-like protein 2

ORM1-like protein 2 (ORMDL2) is a protein from Homo sapiens identified by UniProt accession Q53FV1, 153 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	ORM1-like protein 2
UniProt accession	Q53FV1
Gene	ORMDL2
Organism	Homo sapiens
Length	153 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

Myopia · score 0.05
IGA glomerulonephritis · score 0.02
systemic juvenile idiopathic arthritis · score 0.01
ulcerative colitis · score 0.01
ovarian carcinoma · score 0.01
psoriasis · score 0.01
Obesity · score 0.00
non-alcoholic steatohepatitis · score 0.00
multiple myeloma · score 0.00
glioblastoma multiforme · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53FV1-F1	alphafold	PREDICTED	94.11	—

Amino-acid sequence (153 residues)

MNVGVAHSEV NPNTRVMNSR GIWLAYIILV GLLHMVLLSI PFFSIPVVWT LTNVIHNLAT YVFLHTVKGT PFETPDQGKA RLLTHWEQMD YGLQFTSSRK FLSISPIVLY LLASFYTKYD AAHFLINTAS LLSVLLPKLP QFHGVRVFGI NKY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards