Interferon-induced protein 44-like (IFI44L)

About Interferon-induced protein 44-like

Interferon-induced protein 44-like (IFI44L) is a protein from Homo sapiens identified by UniProt accession Q53G44, 452 residues long. MolForge cross-references it against 0 known binders and 184 disease associations.

Target properties

Protein name	Interferon-induced protein 44-like
UniProt accession	Q53G44
Gene	IFI44L
Organism	Homo sapiens
Length	452 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (184)

Diseases linked to this target (Open Targets).

response to vaccine · score 0.37
MMR-related febrile seizures · score 0.37
Febrile seizure (within the age range of 3 months to 6 years) · score 0.30
bipolar disorder · score 0.24
CINCA syndrome · score 0.18
schizophrenia · score 0.18
sleep duration · score 0.17
Systemic lupus erythematosus · score 0.09
vital capacity · score 0.08
leukocyte count · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53G44-F1	alphafold	PREDICTED	86.07	—

Amino-acid sequence (452 residues)

MEVTTRLTWN DENHLRKLLG NVSLSLLYKS SVHGGSIEDM VERCSRQGCT ITMAYIDYNM IVAFMLGNYI NLHESSTEPN DSLWFSLQKK NDTTEIETLL LNTAPKIIDE QLVCRLSKTD IFIICRDNKI YLDKMITRNL KLRFYGHRQY LECEVFRVEG IKDNLDDIKR IIKAREHRNR LLADIRDYRP YADLVSEIRI LLVGPVGSGK SSFFNSVKSI FHGHVTGQAV VGSDITSITE RYRIYSVKDG KNGKSLPFML CDTMGLDGAE GAGLCMDDIP HILKGCMPDR YQFNSRKPIT PEHSTFITSP SLKDRIHCVA YVLDINSIDN LYSKMLAKVK QVHKEVLNCG IAYVALLTKV DDCSEVLQDN FLNMSRSMTS QSRVMNVHKM LGIPISNILM VGNYASDLEL DPMKDILILS ALRQMLRAAD DFLEDLPLEE TGAIERALQP CI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards