Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12)

About Very-long-chain 3-oxoacyl-CoA reductase

Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) is a protein from Homo sapiens identified by UniProt accession Q53GQ0, 312 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Very-long-chain 3-oxoacyl-CoA reductase
UniProt accession	Q53GQ0
Gene	HSD17B12
Organism	Homo sapiens
Length	312 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

Alzheimer disease · score 0.47
body mass index · score 0.46
Parkinson disease · score 0.46
neurodegenerative disease · score 0.46
lysosomal storage disease · score 0.46
multiple sclerosis · score 0.46
body fat percentage · score 0.44
vital capacity · score 0.44
high density lipoprotein cholesterol measurement · score 0.39
serum alanine aminotransferase measurement · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53GQ0-F1	alphafold	PREDICTED	94.39	—

Amino-acid sequence (312 residues)

MESALPAAGF LYWVGAGTVA YLALRISYSL FTALRVWGVG NEAGVGPGLG EWAVVTGSTD GIGKSYAEEL AKHGMKVVLI SRSKDKLDQV SSEIKEKFKV ETRTIAVDFA SEDIYDKIKT GLAGLEIGIL VNNVGMSYEY PEYFLDVPDL DNVIKKMINI NILSVCKMTQ LVLPGMVERS KGAILNISSG SGMLPVPLLT IYSATKTFVD FFSQCLHEEY RSKGVFVQSV LPYFVATKLA KIRKPTLDKP SPETFVKSAI KTVGLQSRTN GYLIHALMGS IISNLPSWIY LKIVMNMNKS TRAHYLKKTK KN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards