About Transmembrane 4 L6 family member 20
Transmembrane 4 L6 family member 20 (TM4SF20) is a protein
from Homo sapiens identified by UniProt accession
Q53R12, 229 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Transmembrane 4 L6 family member 20 |
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| UniProt accession | Q53R12 |
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| Gene | TM4SF20 |
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| Organism | Homo sapiens |
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| Length | 229 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- language impairment · score 0.41
- cortical thickness · score 0.13
- Barrett's esophagus · score 0.08
- hemoglobin measurement · score 0.07
- hematocrit · score 0.06
- hepatocellular carcinoma · score 0.05
- esophageal adenocarcinoma · score 0.05
- breast carcinoma · score 0.04
- Crohn's disease · score 0.04
- red blood cell density measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53R12-F1 | alphafold | PREDICTED | 73.43 | — |
Amino-acid sequence (229 residues)
MTCCEGWTSC NGFSLLVLLL LGVVLNAIPL IVSLVEEDQF SQNPISCFEW WFPGIIGAGL MAIPATTMSL TARKRACCNN RTGMFLSSLF SVITVIGALY CMLISIQALL KGPLMCNSPS NSNANCEFSL KNISDIHPES FNLQWFFNDS CAPPTGFNKP TSNDTMASGW RASSFHFDSE ENKHRLIHFS VFLGLLLVGI LEVLFGLSQI VIGFLGCLCG VSKRRSQIV
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