Transmembrane protein 177 (TMEM177)

About Transmembrane protein 177

Transmembrane protein 177 (TMEM177) is a protein from Homo sapiens identified by UniProt accession Q53S58, 311 residues long. MolForge cross-references it against 0 known binders and 5 disease associations.

Target properties

Protein name	Transmembrane protein 177
UniProt accession	Q53S58
Gene	TMEM177
Organism	Homo sapiens
Length	311 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (5)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.24
lung carcinoma · score 0.02
systemic juvenile idiopathic arthritis · score 0.01
non-small cell lung carcinoma · score 0.00
neoplasm · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q53S58-F1	alphafold	PREDICTED	90.47	—

Amino-acid sequence (311 residues)

MAGPLWRTAA FVQRHRTGLL VGSCAGLFGV PISYHLFPDP VVQWLYQYWP QGQPAPLPPQ LQSLFQEVLQ DIGVPSGHCY KPFTTFTFQP VSAGFPRLPA GAVVGIPASF LGDLVINTNH PVVIHGHTVD WRSPAGARLR ASLTLSREAQ KFALAREVVY LESSTTAVHA LLAPACLAGT WALGVGAKYT LGLHAGPMNL RAAFSLVAAV AGFVAYAFSQ DSLTHAVESW LDRRTASLSA AYACGGVEFY EKLLSGNLAL RSLLGKDGEK LYTPSGNIVP RHLFRIKHLP YTTRRDSVLQ MWRGMLNPGR S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards