About TATA box-binding protein-associated factor RNA polymerase I subunit B
TATA box-binding protein-associated factor RNA polymerase I subunit B (TAF1B) is a protein
from Homo sapiens identified by UniProt accession
Q53T94, 588 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | TATA box-binding protein-associated factor RNA polymerase I subunit B |
|---|
| UniProt accession | Q53T94 |
|---|
| Gene | TAF1B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 588 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (34)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- Cleft palate · score 0.28
- cleft lip · score 0.28
- calcium measurement · score 0.28
- blood phosphate measurement · score 0.27
- endometrial cancer · score 0.25
- urate measurement · score 0.24
- bone density · score 0.24
- breast adenocarcinoma · score 0.11
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q53T94-F1 | alphafold | PREDICTED | 78.71 | — |
Amino-acid sequence (588 residues)
MDLEEAEEFK ERCTQCAAVS WGLTDEGKYY CTSCHNVTER YQEVTNTDLI PNTQIKALNR GLKKKNNTEK GWDWYVCEGF QYILYQQAEA LKNLGVGPEL KNDVLHNFWK RYLQKSKQAY CKNPVYTTGR KPTVLEDNLS HSDWASEPEL LSDVSCPPFL ESGAESQSDI HTRKPFPVSK ASQSETSVCS GSLDGVEYSQ RKEKGIVKMT MPQTLAFCYL SLLWQREAIT LSDLLRFVEE DHIPYINAFQ HFPEQMKLYG RDRGIFGIES WPDYEDIYKK TVEVGTFLDL PRFPDITEDC YLHPNILCMK YLMEVNLPDE MHSLTCHVVK MTGMGEVDFL TFDPIAKMAK TVKYDVQAVA IIVVVLKLLF LLDDSFEWSL SNLAEKHNEK NKKDKPWFDF RKWYQIMKKA FDEKKQKWEE ARAKYLWKSE KPLYYSFVDK PVAYKKREMV VNLQKQFSTL VESTATAGKK SPSSFQFNWT EEDTDRTCFH GHSLQGVLKE KGQSLLTKNS LYWLSTQKFC RCYCTHVTTY EESNYSLSYQ FILNLFSFLL RIKTSLLHEE VSLVEKKLFE KKYSVKRKKS RSKKVRRH
Explore TATA box-binding protein-associated factor RNA polymerase I subunit B with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets