About Protein Largen
Protein Largen (PRR16) is a protein
from Homo sapiens identified by UniProt accession
Q569H4, 304 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Protein Largen |
|---|
| UniProt accession | Q569H4 |
|---|
| Gene | PRR16 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 304 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- FEV/FVC ratio · score 0.39
- body height · score 0.36
- pulse pressure measurement · score 0.36
- optic cup area measurement · score 0.33
- complement C1r subcomponent measurement · score 0.32
- neurofibrillary tangles measurement · score 0.31
- unipolar depression · score 0.31
- mood disorder · score 0.31
- self reported educational attainment · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q569H4-F1 | alphafold | PREDICTED | 63.13 | — |
Amino-acid sequence (304 residues)
MSAKSKGNPS SSCPAEGPPA ASKTKVKEQI KIIVEDLELV LGDLKDVAKE LKEVVDQIDT LTSDLQLEDE MTDSSKTDTL NSSSSGTTAS SLEKIKVQAN APLIKPPAHP SAILTVLRKP NPPPPPPRLT PVKCEDPKRV VPTANPVKTN GTLLRNGGLP GGPNKIPNGD ICCIPNSNLD KAPVQLLMHR PEKDRCPQAG PRERVRFNEK VQYHGYCPDC DTRYNIKNRE VHLHSEPVHP PGKIPHQGPP LPPTPHLPPF PLENGGMGIS HSNSFPPIRP ATVPPPTAPK PQKTILRKST TTTV
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