About Coiled-coil domain-containing protein 157
Coiled-coil domain-containing protein 157 (CCDC157) is a protein
from Homo sapiens identified by UniProt accession
Q569K6, 752 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 157 |
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| UniProt accession | Q569K6 |
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| Gene | CCDC157 |
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| Organism | Homo sapiens |
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| Length | 752 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (122)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- sex hormone-binding globulin measurement · score 0.29
- white matter microstructure measurement · score 0.24
- hematocrit · score 0.23
- calcium measurement · score 0.22
- HbA1c measurement · score 0.19
- platelet count · score 0.19
- pulse pressure measurement · score 0.18
- total cholesterol measurement · score 0.18
- platelet crit · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q569K6-F1 | alphafold | PREDICTED | 71.89 | — |
Amino-acid sequence (752 residues)
MAHLLGSQAC MESLRTDLTD LQGAIVDVFS RAGPVRFPSW KFPDRMACDL DMVALLEHYD HVPGDPEFTQ LSHAVLLELV IDRLLLLLQS CMSYLENLGS EQMMPPAQAA GPCMSVGLTV RRFWDSLLRL GTLHQQPLPQ KGANQRETPT SKPTTKGEPA RSPEYLTTKL IKPSSPVLGL PQTCQEPESI PVRASLQFPA TTFKNTRSVH SQTIETALVP CDACASVQGS LQKVGKVVIS LCQSQNLPSS LGQFQQLVQD SMGLRPLPAA TVGRWAAEQR KDLTRLSKHV EALRAQLEEA EGQKDGLRKQ AGKLEQALKQ EQGARRRQAE EDEQCLSEWE HDKQQLLTET SDLKTKMATL ERELKQQRES TQAVEAKAQQ LQEEGERRAA AERQVQQLEE QVQQLEAQVQ LLVGRLEGAG QQVCWASTEL DKEKARVDSM VRHQESLQAK QRALLKQLDS LDQEREELRG SLDEAEAQRA RVEEQLQSER EQGQCQLRAQ QELLQSLQRE KQGLEQATTD LRLTILELER ELEELKERER LLVAFPDLHR PTETQIHGGR SSSVESQITC PTDSGNVTDH MERQVQSNDI RIRVLQEENG RLQSMLSKIR EVAQQGGLKL IPQDRLWSPS SKGTQGATPP VQAKSTSPGP LGRQHLPSSR TGRTLLGQPC TSPPRQPCTS PPRQPCTSPP RQPCTSPSRQ PCSQPSKSLL EGVTHLDTCT QNPIKVLVRL RKRLSPGRGQ ASSAHQPQER PM
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