About Transmembrane protein 41B
Transmembrane protein 41B (TMEM41B) is a protein
from Homo sapiens identified by UniProt accession
Q5BJD5, 291 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Transmembrane protein 41B |
|---|
| UniProt accession | Q5BJD5 |
|---|
| Gene | TMEM41B |
|---|
| Organism | Homo sapiens |
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| Length | 291 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- Flavivirus Infections · score 0.08
- infect · score 0.07
- infection · score 0.07
- dengue disease · score 0.06
- severe malarial anemia · score 0.05
- hypertriglyceridemia 2 · score 0.04
- cholesterol-ester transfer protein deficiency · score 0.04
- Combined hyperlipidemia · score 0.04
- viral disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5BJD5-F1 | alphafold | PREDICTED | 82.24 | — |
Amino-acid sequence (291 residues)
MAKGRVAERS QLGAHHTTPV GDGAAGTRGL AAPGSRDHQK EKSWVEAGSA RMSLLILVSI FLSAAFVMFL VYKNFPQLSE EERVNMKVPR DMDDAKALGK VLSKYKDTFY VQVLVAYFAT YIFLQTFAIP GSIFLSILSG FLYPFPLALF LVCLCSGLGA SFCYMLSYLV GRPVVYKYLT EKAVKWSQQV ERHREHLINY IIFLRITPFL PNWFINITSP VINVPLKVFF IGTFLGVAPP SFVAIKAGTT LYQLTTAGEA VSWNSIFILM ILAVLSILPA IFQKKLKQKF E
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