About N-acetyltransferase ESCO1
N-acetyltransferase ESCO1 (ESCO1) is a protein
from Homo sapiens identified by UniProt accession
Q5FWF5, 840 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | N-acetyltransferase ESCO1 |
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| UniProt accession | Q5FWF5 |
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| Gene | ESCO1 |
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| Organism | Homo sapiens |
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| Length | 840 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- phosphatidylcholine measurement · score 0.31
- neurodegenerative disease · score 0.28
- neuroimaging measurement · score 0.22
- phospholipid measurement · score 0.22
- brain volume measurement · score 0.21
- endometrial cancer · score 0.14
- creatinine measurement · score 0.12
- mean corpuscular volume · score 0.11
- glioblastoma multiforme · score 0.10
- urinary bladder cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5FWF5-F1 | alphafold | PREDICTED | 52.38 | — |
Amino-acid sequence (840 residues)
MMSIQEKSKE NSSKVTKKSD DKNSETEIQD SQKNLAKKSG PKETIKSQAK SSSESKINQP ELETRMSTRS SKAASNDKAT KSINKNTVTV RGYSQESTKK KLSQKKLVHE NPKANEQLNR RSQRLQQLTE VSRRSLRSRE IQGQVQAVKQ SLPPTKKEQC SSTQSKSNKT SQKHVKRKVL EVKSDSKEDE NLVINEVINS PKGKKRKVEH QTACACSSQC TQGSEKCPQK TTRRDETKPV PVTSEVKRSK MATSVVPKKN EMKKSVHTQV NTNTTLPKSP QPSVPEQSDN ELEQAGKSKR GSILQLCEEI AGEIESDNVE VKKESSQMES VKEEKPTEIK LEETSVERQI LHQKETNQDV QCNRFFPSRK TKPVKCILNG INSSAKKNSN WTKIKLSKFN SVQHNKLDSQ VSPKLGLLRT SFSPPALEMH HPVTQSTFLG TKLHDRNITC QQEKMKEINS EEVKINDITV EINKTTERAP ENCHLANEIK PSDPPLDNQM KHSFDSASNK NFSQCLESKL ENSPVENVTA ASTLLSQAKI DTGENKFPGS APQQHSILSN QTSKSSDNRE TPRNHSLPKC NSHLEITIPK DLKLKEAEKT DEKQLIIDAG QKRFGAVSCN VCGMLYTASN PEDETQHLLF HNQFISAVKY VGWKKERILA EYPDGRIIMV LPEDPKYALK KVDEIREMVD NDLGFQQAPL MCYSRTKTLL FISNDKKVVG CLIAEHIQWG YRVIEEKLPV IRSEEEKVRF ERQKAWCCST LPEPAICGIS RIWVFSMMRR KKIASRMIEC LRSNFIYGSY LSKEEIAFSD PTPDGKLFAT QYCGTGQFLV YNFINGQNST
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