About XK-related protein 4
XK-related protein 4 (XKR4) is a protein
from Homo sapiens identified by UniProt accession
Q5GH76, 650 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | XK-related protein 4 |
|---|
| UniProt accession | Q5GH76 |
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| Gene | XKR4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 650 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.32
- PHF-tau measurement · score 0.29
- thyroid stimulating hormone measurement · score 0.26
- high-risk pregnancy · score 0.17
- Hernia · score 0.09
- neurofibrillary tangles measurement · score 0.09
- sphingomyelin measurement · score 0.07
- body height · score 0.07
- schizophrenia · score 0.06
- Abnormal sperm morphology · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5GH76-F1 | alphafold | PREDICTED | 63.08 | — |
Amino-acid sequence (650 residues)
MAAKSDGRLK MKKSSDVAFT PLQNSDHSGS VQGLAPGLPS GSGAEDEEAA GGGCCPDGGG CSRCCCCCAG SGGSAGSGGS GGVAGPGGGG AGSAALCLRL GREQRRYSLW DCLWILAAVA VYFADVGTDV WLAVDYYLRG QRWWFGLTLF FVVLGSLSVQ VFSFRWFVHD FSTEDSATAA AASSCPQPGA DCKTVVGGGS AAGEGEARPS TPQRQASNAS KSNIAAANSG SNSSGATRAS GKHRSASCSF CIWLLQSLIH ILQLGQIWRY FHTIYLGIRS RQSGENDRWR FYWKMVYEYA DVSMLHLLAT FLESAPQLVL QLCIIVQTHS LQALQGFTAA ASLVSLAWAL ASYQKALRDS RDDKKPISYM AVIIQFCWHF FTIAARVITF ALFASVFQLY FGIFIVLHWC IMTFWIVHCE TEFCITKWEE IVFDMVVGII YIFSWFNVKE GRTRCRLFIY YFVILLENTA LSALWYLYKA PQIADAFAIP ALCVVFSSFL TGVVFMLMYY AFFHPNGPRF GQSPSCACED PAAAFTLPPD VATSTLRSIS NNRSVVSDRD QKFAERDGCV PVFQVRPTAP STPSSRPPRI EESVIKIDLF RNRYPAWERH VLDRSLRKAI LAFECSPSPP RLQYKDDALI QERLEYETTL
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