XK-related protein 3 (XKR3)

About XK-related protein 3

XK-related protein 3 (XKR3) is a protein from Homo sapiens identified by UniProt accession Q5GH77, 459 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	XK-related protein 3
UniProt accession	Q5GH77
Gene	XKR3
Organism	Homo sapiens
Length	459 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.26
PHF-tau measurement · score 0.16
metabolite measurement · score 0.13
drug use measurement · score 0.02
cat-eye syndrome · score 0.01
aneurysm · score 0.00
cholesteryl ester measurement · score 0.00
acute lymphoblastic leukemia · score 0.00
Pneumonia · score 0.00
Sepsis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5GH77-F1	alphafold	PREDICTED	76.89	—

Amino-acid sequence (459 residues)

METVFEEMDE ESTGGVSSSK EEIVLGQRLH LSFPFSIIFS TVLYCGEVAF GLYMFEIYRK ANDTFWMSFT ISFIIVGAIL DQIILMFFNK DLRRNKAALL FWHILLLGPI VRCLHTIRNY HKWLKNLKQE KEETQVSITK RNTMLEREIA FSIRDNFMQQ KAFKYMSVIQ AFLGSVPQLI LQMYISLTIR EWPLNRALLM TFSLLSVTYG AIRCNILAIQ ISNDDTTIKL PPIEFFCVVM WRFLEVISRV VTLAFFIASL KLKSLPVLLI IYFVSLLAPW LEFWKSGAHL PGNKENNSNM VGTVLMLFLI TLLYAAINFS CWSAVKLQLS DDKIIDGRQR WGHRILHYSF QFLENVIMIL VFRFFGGKTL LNCCDSLIAV QLIISYLLAT GFMLLFYQYL YPWQSGKVLP GRTENQPEAP YYYVNIEKTE KNKNKQLRNY CHSCNRVGYF SIRKSMTCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards