About RRP12-like protein
RRP12-like protein (RRP12) is a protein
from Homo sapiens identified by UniProt accession
Q5JTH9, 1297 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | RRP12-like protein |
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| UniProt accession | Q5JTH9 |
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| Gene | RRP12 |
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| Organism | Homo sapiens |
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| Length | 1297 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- monocyte count · score 0.26
- leukocyte count · score 0.22
- neutrophil count · score 0.22
- monocyte percentage of leukocytes · score 0.17
- myeloid white cell count · score 0.15
- lymphocyte:monocyte ratio · score 0.15
- platelet count · score 0.15
- granulocyte percentage of myeloid white cells · score 0.12
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5JTH9-F1 | alphafold | PREDICTED | 78.65 | — |
Amino-acid sequence (1297 residues)
MGRSGKLPSG VSAKLKRWKK GHSSDSNPAI CRHRQAARSR FFSRPSGRSD LTVDAVKLHN ELQSGSLRLG KSEAPETPME EEAELVLTEK SSGTFLSGLS DCTNVTFSKV QRFWESNSAA HKEICAVLAA VTEVIRSQGG KETETEYFAA LMTTMEAVES PESLAAVAYL LNLVLKRVPS PVLIKKFSDT SKAFMDIMSA QASSGSTSVL RWVLSCLATL LRKQDLEAWG YPVTLQVYHG LLSFTVHPKP KIRKAAQHGV CSVLKGSEFM FEKAPAHHPA AISTAKFCIQ EIEKSGGSKE ATTTLHMLTL LKDLLPCFPE GLVKSCSETL LRVMTLSHVL VTACAMQAFH SLFHARPGLS TLSAELNAQI ITALYDYVPS ENDLQPLLAW LKVMEKAHIN LVRLQWDLGL GHLPRFFGTA VTCLLSPHSQ VLTAATQSLK EILKECVAPH MADIGSVTSS ASGPAQSVAK MFRAVEEGLT YKFHAAWSSV LQLLCVFFEA CGRQAHPVMR KCLQSLCDLR LSPHFPHTAA LDQAVGAAVT SMGPEVVLQA VPLEIDGSEE TLDFPRSWLL PVIRDHVQET RLGFFTTYFL PLANTLKSKA MDLAQAGSTV ESKIYDTLQW QMWTLLPGFC TRPTDVAISF KGLARTLGMA ISERPDLRVT VCQALRTLIT KGCQAEADRA EVSRFAKNFL PILFNLYGQP VAAGDTPAPR RAVLETIRTY LTITDTQLVN SLLEKASEKV LDPASSDFTR LSVLDLVVAL APCADEAAIS KLYSTIRPYL ESKAHGVQKK AYRVLEEVCA SPQGPGALFV QSHLEDLKKT LLDSLRSTSS PAKRPRLKCL LHIVRKLSAE HKEFITALIP EVILCTKEVS VGARKNAFAL LVEMGHAFLR FGSNQEEALQ CYLVLIYPGL VGAVTMVSCS ILALTHLLFE FKGLMGTSTV EQLLENVCLL LASRTRDVVK SALGFIKVAV TVMDVAHLAK HVQLVMEAIG KLSDDMRRHF RMKLRNLFTK FIRKFGFELV KRLLPEEYHR VLVNIRKAEA RAKRHRALSQ AAVEEEEEEE EEEEPAQGKG DSIEEILADS EDEEDNEEEE RSRGKEQRKL ARQRSRAWLK EGGGDEPLNF LDPKVAQRVL ATQPGPGRGR KKDHGFKVSA DGRLIIREEA DGNKMEEEEG AKGEDEEMAD PMEDVIIRNK KHQKLKHQKE AEEEELEIPP QYQAGGSGIH RPVAKKAMPG AEYKAKKAKG DVKKKGRPDP YAYIPLNRSK LNRRKKMKLQ GQFKGLVKAA RRGSQVGHKN RRKDRRP
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