Protein DOP1A (DOP1A)

About Protein DOP1A

Protein DOP1A (DOP1A) is a protein from Homo sapiens identified by UniProt accession Q5JWR5, 2465 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Protein DOP1A
UniProt accession	Q5JWR5
Gene	DOP1A
Organism	Homo sapiens
Length	2465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

vitamin D measurement · score 0.26
body height · score 0.17
bone quantitative ultrasound measurement · score 0.10
heel bone mineral density · score 0.10
Crohn's disease · score 0.06
lean body mass · score 0.05
body mass index · score 0.05
fat body mass · score 0.05
hemoglobin D disease · score 0.04
body weight · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5JWR5-F1	alphafold	PREDICTED	66.93	—

Amino-acid sequence (2465 residues)

MNTEELELLS DSKYRNYVAA IDKALKNFEY SSEWADLISA LGKLNKVLQN NAKYQVVPKK LTIGKRLAQC LHPALPGGVH RKALETYEII FKIIGPKRLA KDLFLYSSGL FPLLANAAMS VKPTLLSLYE IYYLPLGKTL KPGLQGLLTG ILPGLEEGSE YYERTNMLLE KVAAAVDQSA FYSALWGSLL TSPAVRLPGI TYVLAHLNRK LSMEDQLYII GSDIELMVEA VSTSVQDSSV LVQRSTLDLI LFCFPFHMSQ ATRPDMIRIL SAALHVVLRR DMSLNRRLYA WLLGFDNNGA IIGPRSTRHS NPEEHATYYF TTFSKELLVQ AMVGILQVNG FGEENTLMQD LKPFRILISL LDKPELGPVI LEDVLIEVFR TLYSQCKAEL DLQTEPPFSK DHAQLSSKLR ENKKTAELIK TANLLFNSFE PYYMWDYVAR WFEECCRRTL HVRLQIGPGD SNDSSELQLT NFCLLVDFLL DIVSLPTRSM RVLCQETYIE IQTEHLPQLL LRMISALTSH LQTLHLSELT DSLRLCSKIL SKVQPPLLSA STGGVLQFPS GQNNSVKEWE DKKVSSVSHE NPTEVFEDGE NPPSSRSSES GFTEFIQYQA DRTDDIDREL SEGQGAAAIP IGSTSSETET ASTVGSEETI IQTPSVVTQG TATRSRKTAQ KTAMQCCLEY VQQFLTRLIN LYIIQNNSFS QSLATEHQGD LGREQGETSK WDRNSQGDVK EKNISKQKTS KEYLSAFLAA CQLFLECSSF PVYIAEGNHT SELRSEKLET DCEHVQPPQW LQTLMNACSQ ASDFSVQSVA ISLVMDLVGL TQSVAMVTGE NINSVEPAQP LSPNQGRVAV VIRPPLTQGN LRYIAEKTEF FKHVALTLWD QLGDGTPQHH QKSVELFYQL HNLVPSSSIC EDVISQQLTH KDKKIRMEAH AKFAVLWHLT RDLHINKSSS FVRSFDRSLF IMLDSLNSLD GSTSSVGQAW LNQVLQRHDI ARVLEPLLLL LLHPKTQRVS VQRVQAERYW NKSPCYPGEE SDKHFMQNFA CSNVSQVQLI TSKGNGEKPL TMDEIENFSL TVNPLSDRLS LLSTSSETIP MVVSDFDLPD QQIEILQSSD SGCSQSSAGD NLSYEVDPET VNAQEDSQMP KESSPDDDVQ QVVFDLICKV VSGLEVESAS VTSQLEIEAM PPKCSDIDPD EETIKIEDDS IQQSQNALLS NESSQFLSVS AEGGHECVAN GISRNSSSPC ISGTTHTLHD SSVASIETKS RQRSHSSIQF SFKEKLSEKV SEKETIVKES GKQPGAKPKV KLARKKDDDK KKSSNEKLKQ TSVFFSDGLD LENWYSCGEG DISEIESDMG SPGSRKSPNF NIHPLYQHVL LYLQLYDSSR TLYAFSAIKA ILKTNPIAFV NAISTTSVNN AYTPQLSLLQ NLLARHRISV MGKDFYSHIP VDSNHNFRSS MYIEILISLC LYYMRSHYPT HVKVTAQDLI GNRNMQMMSI EILTLLFTEL AKVIESSAKG FPSFISDMLS KCKVQKVILH CLLSSIFSAQ KWHSEKMAGK NLVAVEEGFS EDSLINFSED EFDNGSTLQS QLLKVLQRLI VLEHRVMTIP EENETGFDFV VSDLEHISPH QPMTSLQYLH AQPITCQGMF LCAVIRALHQ HCACKMHPQW IGLITSTLPY MGKVLQRVVV SVTLQLCRNL DNLIQQYKYE TGLSDSRPLW MASIIPPDMI LTLLEGITAI IHYCLLDPTT QYHQLLVSVD QKHLFEARSG ILSILHMIMS SVTLLWSILH QADSSEKMTI AASASLTTIN LGATKNLRQQ ILELLGPISM NHGVHFMAAI AFVWNERRQN KTTTRTKVIP AASEEQLLLV ELVRSISVMR AETVIQTVKE VLKQPPAIAK DKKHLSLEVC MLQFFYAYIQ RIPVPNLVDS WASLLILLKD SIQLSLPAPG QFLILGVLNE FIMKNPSLEN KKDQRDLQDV THKIVDAIGA IAGSSLEQTT WLRRNLEVKP SPKIMVDGTN LESDVEDMLS PAMETANITP SVYSVHALTL LSEVLAHLLD MVFYSDEKER VIPLLVNIMH YVVPYLRNHS AHNAPSYRAC VQLLSSLSGY QYTRRAWKKE AFDLFMDPSF FQMDASCVNH WRAIMDNLMT HDKTTFRDLM TRVAVAQSSS LNLFANRDVE LEQRAMLLKR LAFAIFSSEI DQYQKYLPDI QERLVESLRL PQVPTLHSQV FLFFRVLLLR MSPQHLTSLW PTMITELVQV FLLMEQELTA DEDISRTSGP SVAGLETTYT GGNGFSTSYN SQRWLNLYLS ACKFLDLALA LPSENLPQFQ MYRWAFIPEA SDDSGLEVRR QGIHQREFKP YVVRLAKLLR KRAKKNPEED NSGRTLGWEP GHLLLTICTV RSMEQLLPFF NVLSQVFNSK VTSRCGGHSG SPILYSNAFP NKDMKLENHK PCSSKARQKI EEMVEKDFLE GMIKT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards