About Alkaline ceramidase 2
Alkaline ceramidase 2 (ACER2) is a protein
from Homo sapiens identified by UniProt accession
Q5QJU3, 275 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Alkaline ceramidase 2 |
|---|
| UniProt accession | Q5QJU3 |
|---|
| Gene | ACER2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 275 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (53)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.34
- insulin like growth factor measurement · score 0.29
- mean corpuscular volume · score 0.22
- Hepatic fibrosis · score 0.20
- mean corpuscular hemoglobin · score 0.16
- mean corpuscular hemoglobin concentration · score 0.11
- platelet crit · score 0.09
- protein measurement · score 0.08
- hepatocellular carcinoma · score 0.08
- adolescent idiopathic scoliosis · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5QJU3-F1 | alphafold | PREDICTED | 93.19 | — |
Amino-acid sequence (275 residues)
MGAPHWWDQL QAGSSEVDWC EDNYTIVPAI AEFYNTISNV LFFILPPICM CLFRQYATCF NSGIYLIWTL LVVVGIGSVY FHATLSFLGQ MLDELAVLWV LMCALAMWFP RRYLPKIFRN DRGRFKVVVS VLSAVTTCLA FVKPAINNIS LMTLGVPCTA LLIAELKRCD NMRVFKLGLF SGLWWTLALF CWISDRAFCE LLSSFNFPYL HCMWHILICL AAYLGCVCFA YFDAASEIPE QGPVIKFWPN EKWAFIGVPY VSLLCANKKS SVKIT
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