About DDB1- and CUL4-associated factor 10
DDB1- and CUL4-associated factor 10 (DCAF10) is a protein
from Homo sapiens identified by UniProt accession
Q5QP82, 559 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | DDB1- and CUL4-associated factor 10 |
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| UniProt accession | Q5QP82 |
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| Gene | DCAF10 |
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| Organism | Homo sapiens |
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| Length | 559 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.27
- reticulocyte measurement · score 0.21
- hemoglobin D disease · score 0.05
- pulse pressure measurement · score 0.04
- hemoglobin E disease · score 0.04
- dominant beta-thalassemia · score 0.04
- Blackfan-Diamond anemia · score 0.03
- attention deficit hyperactivity disorder · score 0.03
- delta-beta-thalassemia · score 0.03
- Adult-onset autosomal recessive sideroblastic anemia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5QP82-F1 | alphafold | PREDICTED | 69.54 | — |
Amino-acid sequence (559 residues)
MFPFGPHSPG GDGSAGAGAE EPTPHEGQAA ATGPPSPLHP GADATHPPPP ARSPRRPGAP SLSPAPRSGE LGLPGAPESS TASAPGEPSP PSPPCRRPGP DCRAKSRGRH GLGAGLGGPG ARLFGWLKER SLGRGLFVDP ARDNFRTMTS LYGSIHPADS VYLSTRTHGA VFNLEYSPDG SVLTVACEQT EVLLFDPISS KHIKTLSEAH EDCVNNIRFL DNRLFATCSD DTTIALWDLR KLNTKVCTLH GHTSWVKNIE YDTNTRLLVT SGFDGNVIIW DTNRYTEDGC PHKKFFHTRF LMRMRLTPDC SKMLISTSSG YLLILHDLDL TKSLEVGSYP ILRARRTTSS SDLTTSSSSS GPRVSGSPCH HSDSNSSEKH MSRASQREGV SPRNSLEVVT PEVLGESDHG NCITSLQLHP KGWATLLRCS SNSDDEECTC VYEFQEGAPV RPVSPRCSLR LTHYIEEANV GRGYIKELCF SPDGRMISSP HGYGIRLLGF DKQCSELVDC LPKEASPLRV IRSLYSHNDV VLTTKFSPTH CQIASGCLSG RVSLYQPKF
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