About Glutamate-rich protein 3
Glutamate-rich protein 3 (ERICH3) is a protein
from Homo sapiens identified by UniProt accession
Q5RHP9, 1530 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Glutamate-rich protein 3 |
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| UniProt accession | Q5RHP9 |
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| Gene | ERICH3 |
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| Organism | Homo sapiens |
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| Length | 1530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.20
- genetic disorder · score 0.12
- lean body mass · score 0.09
- protein measurement · score 0.06
- attention deficit hyperactivity disorder · score 0.05
- neoplasm · score 0.05
- schizophrenia 15 · score 0.04
- atypical teratoid rhabdoid tumor · score 0.04
- gonorrhea · score 0.04
- glioblastoma multiforme · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5RHP9-F1 | alphafold | PREDICTED | 43.59 | — |
Amino-acid sequence (1530 residues)
MSHSHPAGLL AAYNSLMDKH LAGYFNNTRI RRHLLRSGLI TRSGRILSEK EYKLNMMKRD HQKYIRECLA QAIFHKVLDM ERYHQLEIKK KLETLARKER IQRFKGEHTR RSVENNMPIL SPHPPVGPKS NRGHSVLVDE GHSSPLALTA PRPYTAPGNM QPPIRLQPLP SNPAVETVPK VTSRSRSKTS LLENEALFPI GGKKAVMKFR NSIGNSQRMN SYQLPNINSY MMPIPPPLPP TGKITRENRS ETWRRRRFRP TTAPNGLEPL LTKDSRRIHK TSLHSNAAIT MIYLGKNVHL SSDNPDFRDE IKVYQQHCGG ENLCVYKGKL LEKETFQFIS KRHHGFPFSL TFFLNGMQVN RLSSCCEYKH RKGSRLGGKR GYFGFVCVER SSPCYKCIIA MGLDKKPSLP KSRKEKSTEK GEELKKAEGK VRKEREYVIP KRNEIKENKT SVSAKFSAQE IKTGLKEVVT AVEEMTSKGK PGQEVLEDDQ ENTLKYEYEE DFEVDEEKQG EKSNEEGQAD VQMNGIPQSP LDDKKDNLDP EKESETSSQK APDARDNVKD ENDGCSESEL EEDKQDMKTA SSTSSRSHPY SSDSEDESAV GDREAHTDSS TDESARRSSS QELSENDKPR KSHLPIEESL EIEIEDQEIT KADVETKPMP IDESFENVLK EGTEKGTQEI AEGLSEKSGK HVSAEEKEKD KSKLWEESTA QVKDKKAGLP GLEEGGKDSL PLAYVLALGA PTMNFMVDET AAINSNKESQ QLVQKTYTLE KKEAMEEDEA PQHRDADIVQ GKGEAALWGE AGAVHEAPLR AWKPTAEQPE LAEEFTEKRE IPPGIERGAE GAAEAEGVRR LGEGGSDPIG QAAAKDAVGL SKDEAPEKQA LMLTVLETDK AASEGEQGLE KAVLANEAAA LNLEHLHEVA ALREAATSEE GEAEGGVAVS DVGESEEEAS IDLEDTGPME DTASKREDGS EEAILGGEEP AKERKEVMRT ETRLSPFTGE AEASRMQVSE GSPEEGSLAK EAFLCKEDVE GEEMVTEAEA NREDDRKEIL PKELDLARER RKAERPKTSL RKTDSEREEV TRANALKDED AFKEEQKLKA EEGETETEVR AEEETKAPPN EMGSDAENEA PVEASELSDN PGLLGEDSLK ETVVPIFEAT PGFEKSLENI TALRKEGGGE RLSEARDTEH KDREELSSRE NRALKEGHRQ DGEGALAAPE AEPAGKVQAP EGLIPATGQA EELAAKDHDS CAGLEGRAEG QGGVDVVLRT QEAVAEEDPI MAEKFREEAV DEDPEEEEDK ECTLETEAMQ DRNSEGDGDM EGEGNTQKNE GMGGGRVVAV EVLHGGGETA ETAAEEREVL AGSETAEEKT IANKASSFSD VAEEETWHQQ DELVGKTAAA GKVVVEELAR SGEEVPAAEE MTVTYTTEAG VGTPGALERK TSGLGQEQEE GSEGQEAATG SGDGRQETGA AEKFRLGLSR EGERELSPES LQAMATLPVK PDFTETREKQ QHMVQGESET ADVSPNNVQV
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