Glycoprotein endo-alpha-1,2-mannosidase (MANEA)

About Glycoprotein endo-alpha-1,2-mannosidase

Glycoprotein endo-alpha-1,2-mannosidase (MANEA) is a protein from Homo sapiens identified by UniProt accession Q5SRI9, 462 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	Glycoprotein endo-alpha-1,2-mannosidase
UniProt accession	Q5SRI9
Gene	MANEA
Organism	Homo sapiens
Length	462 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

aspartate aminotransferase measurement · score 0.37
sex hormone-binding globulin measurement · score 0.33
blood protein measurement · score 0.29
arterial stiffness measurement · score 0.05
infection · score 0.04
infect · score 0.04
neoplasm · score 0.03
social anxiety disorder · score 0.02
panic disorder · score 0.02
Acute hepatic failure · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5SRI9-F1	alphafold	PREDICTED	86.45	—

Amino-acid sequence (462 residues)

MAKFRRRTCI ILALFILFIF SLMMGLKMLR PNTATFGAPF GLDLLPELHQ RTIHLGKNFD FQKSDRINSE TNTKNLKSVE ITMKPSKASE LNLDELPPLN NYLHVFYYSW YGNPQFDGKY IHWNHPVLEH WDPRIAKNYP QGRHNPPDDI GSSFYPELGS YSSRDPSVIE THMRQMRSAS IGVLALSWYP PDVNDENGEP TDNLVPTILD KAHKYNLKVT FHIEPYSNRD DQNMYKNVKY IIDKYGNHPA FYRYKTKTGN ALPMFYVYDS YITKPEKWAN LLTTSGSRSI RNSPYDGLFI ALLVEEKHKY DILQSGFDGI YTYFATNGFT YGSSHQNWAS LKLFCDKYNL IFIPSVGPGY IDTSIRPWNT QNTRNRINGK YYEIGLSAAL QTRPSLISIT SFNEWHEGTQ IEKAVPKRTS NTVYLDYRPH KPGLYLELTR KWSEKYSKER ATYALDRQLP VS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards