About PGC-1 and ERR-induced regulator in muscle protein 1
PGC-1 and ERR-induced regulator in muscle protein 1 (PERM1) is a protein
from Homo sapiens identified by UniProt accession
Q5SV97, 790 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | PGC-1 and ERR-induced regulator in muscle protein 1 |
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| UniProt accession | Q5SV97 |
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| Gene | PERM1 |
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| Organism | Homo sapiens |
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| Length | 790 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- Renal tubular epithelial cell apoptosis · score 0.33
- Neutrophil inclusion bodies · score 0.33
- congenital myasthenic syndrome 8 · score 0.33
- alcohol consumption measurement · score 0.19
- total blood protein measurement · score 0.08
- mitochondrial DNA measurement · score 0.05
- apolipoprotein A 1 measurement · score 0.05
- heel bone mineral density · score 0.05
- serum gamma-glutamyl transferase measurement · score 0.04
- drug use measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5SV97-F1 | alphafold | PREDICTED | 44.43 | — |
Amino-acid sequence (790 residues)
MENFQYSVQL SDQDWAEFSA TADECGLLQA GLASGDELLS SDIDQGDSSG SSPPRAPPLP TGQLAAGGRS RRGCEEEDVA TQQPVSRSQG EPVLALGTGQ QTPSTSARAE APPSLGPGAS PPSQFSSCPG PASSGDQMQR LLQGPAPRPP GEPPGSPKSP GHSTGSQRPP DSPGAPPRSP SRKKRRAVGA KGGGHTGASA SAQTGSPLLP AASPETAKLM AKAGQEELGP GPAGAPEPGP RSPVQEDRPG PGLGLSTPVP VTEQGTDQIR TPRRAKLHTV STTVWEALPD VSRAKSDMAV STPASEPQPD RDMAVSTPAS EPQSDRDMAV STPASEPQPD TDMAVSTPAS EPQPDRDMAV SIPASKPQSD TAVSTPASEP QSSVALSTPI SKPQLDTDVA VSTPASKHGL DVALPTAGPV AKLEVASSPP VSEAVPRMTE SSGLVSTPVP RADAAGLAWP PTRRAGPDVV EMEAVVSEPS AGAPGCCSGA PALGLTQVPR KKKVRFSVAG PSPNKPGSGQ ASARPSAPQT ATGAHGGPGA WEAVAVGPRP HQPRILKHLP RPPPSAVTRV GPGSSFAVTL PEAYEFFFCD TIEENEEAEA AAAGQDPAGV QWPDMCEFFF PDVGAQRSRR RGSPEPLPRA DPVPAPIPGD PVPISIPEVY EHFFFGEDRL EGVLGPAVPL PLQALEPPRS ASEGAGPGTP LKPAVVERLH LALRRAGELR GPVPSFAFSQ NDMCLVFVAF ATWAVRTSDP HTPDAWKTAL LANVGTISAI RYFRRQVGQG RRSHSPSPSS
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