About Transmembrane protein 69
Transmembrane protein 69 (TMEM69) is a protein
from Homo sapiens identified by UniProt accession
Q5SWH9, 247 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Transmembrane protein 69 |
|---|
| UniProt accession | Q5SWH9 |
|---|
| Gene | TMEM69 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 247 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- body mass index · score 0.17
- spinal stenosis · score 0.14
- body fat percentage · score 0.11
- platelet count · score 0.11
- body height · score 0.10
- age-related hearing impairment · score 0.10
- brain measurement · score 0.10
- cortical surface area measurement · score 0.07
- mean corpuscular volume · score 0.07
- vitamin D measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5SWH9-F1 | alphafold | PREDICTED | 74.07 | — |
Amino-acid sequence (247 residues)
MLRFIQKFSQ ASSKILKYSF PVGLRTSRTD ILSLKMSLQQ NFSPCPRPWL SSSFPAYMSK TQCYHTSPCS FKKQQKQALL ARPSSTITYL TDSPKPALCV TLAGLIPFVA PPLVMLMTKT YIPILAFTQM AYGASFLSFL GGIRWGFALP EGSPAKPDYL NLASSAAPLF FSWFAFLISE RLSEAIVTVI MGMGVAFHLE LFLLPHYPNW FKALRIVVTL LATFSFIITL VVKSSFPEKG HKRPGQV
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