28S rRNA (uridine-N(3))-methyltransferase (SPOUT1)

About 28S rRNA (uridine-N(3))-methyltransferase

28S rRNA (uridine-N(3))-methyltransferase (SPOUT1) is a protein from Homo sapiens identified by UniProt accession Q5T280, 376 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	28S rRNA (uridine-N(3))-methyltransferase
UniProt accession	Q5T280
Gene	SPOUT1
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

Neurodevelopmental disorder · score 0.40
serum metabolite measurement · score 0.19
serum albumin measurement · score 0.18
bilirubin measurement · score 0.17
high density lipoprotein cholesterol measurement · score 0.15
triglyceride measurement · score 0.13
BMI-adjusted waist circumference · score 0.13
blood metabolite measurement · score 0.11
BMI-adjusted waist-hip ratio · score 0.10
calcium measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5T280-F1	alphafold	PREDICTED	88.40	—

Amino-acid sequence (376 residues)

MAERGRKRPC GPGEHGQRIE WRKWKQQKKE EKKKWKDLKL MKKLERQRAQ EEQAKRLEEE EAAAEKEDRG RPYTLSVALP GSILDNAQSP ELRTYLAGQI ARACAIFCVD EIVVFDEEGQ DAKTVEGEFT GVGKKGQACV QLARILQYLE CPQYLRKAFF PKHQDLQFAG LLNPLDSPHH MRQDEESEFR EGIVVDRPTR PGHGSFVNCG MKKEVKIDKN LEPGLRVTVR LNQQQHPDCK TYHGKVVSSQ DPRTKAGLYW GYTVRLASCL SAVFAEAPFQ DGYDLTIGTS ERGSDVASAQ LPNFRHALVV FGGLQGLEAG ADADPNLEVA EPSVLFDLYV NTCPGQGSRT IRTEEAILIS LAALQPGLIQ AGARHT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards