Late cornified envelope protein 1A (LCE1A)

About Late cornified envelope protein 1A

Late cornified envelope protein 1A (LCE1A) is a protein from Homo sapiens identified by UniProt accession Q5T7P2, 110 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Late cornified envelope protein 1A
UniProt accession	Q5T7P2
Gene	LCE1A
Organism	Homo sapiens
Length	110 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
prostate adenocarcinoma · score 0.21
esophageal cancer · score 0.17
squamous cell lung carcinoma · score 0.11
melorheostosis · score 0.04
drug use measurement · score 0.02
vitamin D deficiency · score 0.02
cervical carcinoma · score 0.01
neoplasm · score 0.00
Epileptic encephalopathy · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5T7P2-F1	alphafold	PREDICTED	53.36	—

Amino-acid sequence (110 residues)

MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGGC SSGGGGCCLS HHRRHRSHRH RLQSSGCCSQ PSGGSSCCGG DSGQHSGGCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards