About Immediate early response gene 5-like protein
Immediate early response gene 5-like protein (IER5L) is a protein
from Homo sapiens identified by UniProt accession
Q5T953, 404 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Immediate early response gene 5-like protein |
|---|
| UniProt accession | Q5T953 |
|---|
| Gene | IER5L |
|---|
| Organism | Homo sapiens |
|---|
| Length | 404 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (61)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- mean reticulocyte volume · score 0.36
- diet measurement · score 0.30
- protein measurement · score 0.27
- forced expiratory volume · score 0.27
- chronotype measurement · score 0.27
- daytime rest measurement · score 0.25
- intelligence · score 0.23
- blood metabolite measurement · score 0.23
- atopic eczema · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5T953-F1 | alphafold | PREDICTED | 56.46 | — |
Amino-acid sequence (404 residues)
MECALDAQSL ISISLRKIHS SRTQRGGIKL HKNLLVSYVL RNARQLYLSE RYAELYRRQQ QQQQQQPPHH QHQHLAYAAP GMPASAADFG PLQLGGGGDA EAREPAARHQ LHQLHQLHQL HLQQQLHQHQ HPAPRGCAAA AAAGAPAGGA GALSELPGCA ALQPPHGAPH RGQPLEPLQP GPAPLPLPLP PPAPAALCPR DPRAPAACSA PPGAAPPAAA ASPPASPAPA SSPGFYRGAY PTPSDFGLHC SSQTTVLDLD THVVTTVENG YLHQDCCASA HCPCCGQGAP GPGLASAAGC KRKYYPGQEE EEDDEEDAGG LGAEPPGGAP FAPCKRARFE DFCPDSSPDA SNISNLISIF GSGFSGLVSR QPDSSEQPPP LNGQLCAKQA LASLGAWTRA IVAF
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