About E3 ubiquitin-protein ligase RNF187
E3 ubiquitin-protein ligase RNF187 (RNF187) is a protein
from Homo sapiens identified by UniProt accession
Q5TA31, 235 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF187 |
|---|
| UniProt accession | Q5TA31 |
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| Gene | RNF187 |
|---|
| Organism | Homo sapiens |
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| Length | 235 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (23)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.10
- osteosarcoma · score 0.07
- esophageal squamous cell carcinoma · score 0.06
- triple-negative breast cancer · score 0.05
- neoplasm · score 0.05
- cancer · score 0.03
- non-small cell lung carcinoma · score 0.03
- ovarian carcinoma · score 0.03
- malaria · score 0.01
- COVID-19 · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TA31-F1 | alphafold | PREDICTED | 70.72 | — |
Amino-acid sequence (235 residues)
MALPAGPAEA ACALCQRAPR EPVRADCGHR FCRACVVRFW AEEDGPFPCP ECADDCWQRA VEPGRPPLSR RLLALEEAAA APARDGPASE AALQLLCRAD AGPLCAACRM AAGPEPPEWE PRWRKALRGK ENKGSVEIMR KDLNDARDLH GQAESAAAVW KGHVMDRRKK ALTDYKKLRA FFVEEEEHFL QEAEKEEGLP EDELADPTER FRSLLQAVSE LEKKHRNLGL SMLLQ
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