About Collagen alpha-1(XIII) chain
Collagen alpha-1(XIII) chain (COL13A1) is a protein
from Homo sapiens identified by UniProt accession
Q5TAT6, 717 residues long.
MolForge cross-references it against 0 known binders and
257 disease associations.
Target properties
| Protein name | Collagen alpha-1(XIII) chain |
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| UniProt accession | Q5TAT6 |
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| Gene | COL13A1 |
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| Organism | Homo sapiens |
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| Length | 717 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (257)
Diseases linked to this target (Open Targets).
- Congenital myasthenic syndromes · score 0.73
- Postsynaptic congenital myasthenic syndromes · score 0.38
- Presynaptic congenital myasthenic syndromes · score 0.37
- congenital myasthenic syndrome · score 0.37
- optic disc size measurement · score 0.32
- neurofibrillary tangles measurement · score 0.31
- PR interval · score 0.29
- type 2 diabetes mellitus · score 0.27
- breast adenocarcinoma · score 0.26
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TAT6-F1 | alphafold | PREDICTED | 55.61 | — |
Amino-acid sequence (717 residues)
MVAERTHKAA ATGARGPGEL GAPGTVALVA ARAERGARLP SPGSCGLLTL ALCSLALSLL AHFRTAELQA RVLRLEAERG EQQMETAILG RVNQLLDEKW KLHSRRRREA PKTSPGCNCP PGPPGPTGRP GLPGDKGAIG MPGRVGSPGD AGLSIIGPRG PPGQPGTRGF PGFPGPIGLD GKPGHPGPKG DMGLTGPPGQ PGPQGQKGEK GQCGEYPHRE CLSSMPAALR SSQIIALKLL PLLNSVRLAP PPVIKRRTFQ GEQSQASIQG PPGPPGPPGP SGPLGHPGLP GPMGPPGLPG PPGPKGDPGI QGYHGRKGER GMPGMPGKHG AKGAPGIAVA GMKGEPGIPG TKGEKGAEGS PGLPGLLGQK GEKGDAGNSI GGGRGEPGPP GLPGPPGPKG EAGVDGQVGP PGQPGDKGER GAAGEQGPDG PKGSKGEPGK GEMVDYNGNI NEALQEIRTL ALMGPPGLPG QIGPPGAPGI PGQKGEIGLP GPPGHDGEKG PRGKPGDMGP PGPQGPPGKD GPPGVKGENG HPGSPGEKGE KGETGQAGSP GEKGEAGEKG NPGAEVPGLP GPEGPPGPPG LQGVPGPKGE AGLDGAKGEK GFQGEKGDRG PLGLPGASGL DGRPGPPGTP GPIGVPGPAG PKGERGSKGD PGMTGPTGAA GLPGLHGPPG DKGNRGERGK KGSRGPKGDK GDQGAPGLDA PCPLGEDGLP VQGCWNK
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