About Protein furry homolog
Protein furry homolog (FRY) is a protein
from Homo sapiens identified by UniProt accession
Q5TBA9, 3013 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Protein furry homolog |
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| UniProt accession | Q5TBA9 |
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| Gene | FRY |
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| Organism | Homo sapiens |
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| Length | 3013 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (67)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.46
- platelet count · score 0.41
- schizophrenia · score 0.33
- PHF-tau measurement · score 0.32
- creatinine measurement · score 0.30
- body height · score 0.29
- peak expiratory flow · score 0.28
- Abnormality of refraction · score 0.27
- DNA methylation · score 0.26
- autosomal recessive non-syndromic intellectual disability · score 0.18
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (3013 residues)
MASQQDSGFF EISIKYLLKS WSNTSPVGNG YIKPPVPPAS GTHREKGPPT MLPINVDPDS KPGEYVLKSL FVNFTTQAER KIRIIMAEPL EKPLTKSLQR GEDPQFDQVI SSMSSLSEYC LPSILRTLFD WYKRQNGIED ESHEYRPRTS NKSKSDEQQR DYLMERRDLA IDFIFSLVLI EVLKQIPLHP VIDSLIHDVI NLAFKHFKYK EGYLGPNTGN MHIVADLYAE VIGVLAQAKF PAVKKKFMAE LKELRHKEQN PYVVQSIISL IMGMKFFRIK MYPVEDFEAS LQFMQECAHY FLEVKDKDIK HALAGLFVEI LVPVAAAVKN EVNVPCLRNF VESLYDTTLE LSSRKKHSLA LYPLVTCLLC VSQKQLFLNR WHIFLNNCLS NLKNKDPKMA RVALESLYRL LWVYMIRIKC ESNTATQSRL ITIITTLFPK GSRGVVPRDM PLNIFVKIIQ FIAQERLDFA MKEIIFDFLC VGKPAKAFSL NPERMNIGLR AFLVIADSLQ QKDGEPPMPV TGAVLPSGNT LRVKKTYLSK TLTEEEAKMI GMSLYYSQVR KAVDNILRHL DKEVGRCMML TNVQMLNKEP EDMITGERKP KIDLFRTCVA AIPRLLPDGM SKLELIDLLA RLSIHMDDEL RHIAQNSLQG LLVDFSDWRE DVLFGFTNFL LREVNDMHHT LLDSSLKLLL QLLTQWKLVI QTQGKVYEQA NKIRNSELIA NGSSHRIQSE RGPHCSVLHA VEGFALVLLC SFQVATRKLS VLILKEIRAL FIALGQPEDD DRPMIDVMDQ LSSSILESFI HVAVSDSATL PLTHNVDLQW LVEWNAVLVN SHYDVKSPSH VWIFAQSVKD PWVLCLFSFL RQENLPKHCP TALSYAWPYA FTRLQSVMPL VDPNSPINAK KTSTAGSGDN YVTLWRNYLI LCFGVAKPSI MSPGHLRAST PEIMATTPDG TVSYDNKAIG TPSVGVLLKQ LVPLMRLESI EITESLVLGF GRTNSLVFRE LVEELHPLMK EALERRPENK KRRERRDLLR LQLLRIFELL ADAGVISDST NGALERDTLA LGALFLEYVD LTRMLLEAEN DKEVEILKDI RAHFSAMVAN LIQCVPVHHR RFLFPQQSLR HHLFILFSQW AGPFSIMFTP LDRYSDRNHQ ITRYQYCALK AMSAVLCCGP VFDNVGLSPD GYLYKWLDNI LACQDLRVHQ LGCEVVVLLL ELNPDQINLF NWAIDRCYTG SYQLASGCFK AIATVCGSRN YPFDIVTLLN LVLFKASDTN REIYEISMQL MQILEAKLFV YSKKVAEQRP GSILYGTHGP LPPLYSVSLA LLSCELARMY PELTLPLFSE VSQRFPTTHP NGRQIMLTYL LPWLHNIELV DSRLLLPGSS PSSPEDEVKD REGDVTASHG LRGNGWGSPE ATSLVLNNLM YMTAKYGDEV PGPEMENAWN ALANNEKWSN NLRITLQFLI SLCGVSSDTV LLPYIKKVAI YLCRNNTIQT MEELLFELQQ TEPVNPIVQH CDNPPFYRFT ASSKASAAAS GTTSSSNTVV AGQENFPDAE ENKILKESDE RFSNVIRAHT RLESRYSNSS GGSYDEDKND PISPYTGWLL TITETKQPQP LPMPCTGGCW APLVDYLPET ITPRGPLHRC NIAVIFMTEM VVDHSVREDW ALHLPLLLHA VFLGLDHYRP EVFEHSKKLL LHLLIALSCN SNFHSIASVL LQTREMGEAK TLTVQPAYQP EYLYTGGFDF LREDQSSPVP DSGLSSSSTS SSISLGGSSG NLPQMTQEVE DVDTAAETDE KANKLIEFLT TRAFGPLWCH EDITPKNQNS KSAEQLTNFL RHVVSVFKDS KSGFHLEHQL SEVALQTALA SSSRHYAGRS FQIFRALKQP LSAHALSDLL SRLVEVIGEH GDEIQGYVME ALLTLEAAVD NLSDCLKNSD LLTVLSRSSS PDLSSSSKLT ASRKSTGQLN MNPGTTSGNT ATAERSRHQR SFSVPKKFGV IDRSSDPPRS ATLDRIQACT QQGLSSKTRS SSSLKDSLTD PSHINHPTNL LATIFWVTVA LMESDFEFEY LMALRLLSRL LAHMPLDKAE NREKLEKLQA QLKWADFSGL QQLLLKGFTS LTTTDLTLQL FSLLTPVSKI SMVDASHAIG FPLNVLCLLP QLIQHFENPN QFCKDIAERI AQVCLEEKNP KLSNLAHVMT LYKTHSYTRD CATWVNVVCR YLHEAYADIT LNMVTYLAEL LEKGLPSVQQ PLLQVIYSLL SYMDLSVVPV KQFNVEVLKT IEKYVQSVHW REALNILKLV VSRSASLVLP SYQHSDLSKI EIHRVWTSAS KELPGKTLDF HFDISETPII GRRYDELQNS SGRDGKPRAM AVTRSTSSTS SGSNSNVLVP VSWKRPQYSQ KRTKEKLVHV LSLCGQEVGL SKNPSVIFSS CGDLDLLEHQ TSLVSSEDGA REQENMDDTN SEQQFRVFRD FDFLDVELED GEGESMDNFN WGVRRRSLDS LDKCDMQILE ERQLSGSTPS LNKMHHEDSD ESSEEEDLTA SQILEHSDLI MTLSPSEETN PMELLTTACD STPAEPHSFN TRMSSFDASL PDMNNLQISE GSKAEAVREE EDTTVHEDDL SSSINELPAA FECSDSFSLD MTEGEEKGNR ALDQFTLASF GEGDRGVSPP PSPFFSAILA AFQPAACDDA EEAWRSHINQ LMCDSDGSCA VYTFHVFSSL FKNIQKRFCF LTCDAASYLG DNLRGIGSKF VSSSQMLTSC SECPTLFVDA ETLLSCGLLD KLKFSVLELQ EYLDTYNNRK EATLSWLANC KATFAGGSRD GVITCQPGDS EEKQLELCQR LYKLHFQLLL LFQSYCKLIG QVHEVSSMPE LLNMSRELSD LKKHLKEASA VIAADPLYSD GAWSEPTFTS TEAAIQSMLE CLKNNELGKA LRQIRECRSL WPNDIFGSSS DDEVQTLLNI YFRHQTLGQT GTYALVGSNQ SLTEICTKLM ELNMEIRDMI RRAQSYRVLT TFLPDSSVSG TSL
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