Bcl-2-like protein 15 (BCL2L15)

About Bcl-2-like protein 15

Bcl-2-like protein 15 (BCL2L15) is a protein from Homo sapiens identified by UniProt accession Q5TBC7, 163 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Bcl-2-like protein 15
UniProt accession	Q5TBC7
Gene	BCL2L15
Organism	Homo sapiens
Length	163 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

breast carcinoma · score 0.24
rheumatoid arthritis · score 0.21
autoimmune thyroid disease · score 0.20
type 1 diabetes mellitus · score 0.20
systemic lupus erythematosus · score 0.20
myositis · score 0.20
systemic scleroderma · score 0.20
myocardial infarction · score 0.16
coronary artery disease · score 0.16
mean corpuscular volume · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TBC7-F1	alphafold	PREDICTED	85.58	—

Amino-acid sequence (163 residues)

MKSSQTFEEQ TECIVNTLLM DFLSPTLQVA SRNLCCVDEV DSGEPCSFDV AIIAGRLRML GDQFNGELEA SAKNVIAETI KGQTGAILQD TVESLSKTWC AQDSSLAYER AFLAVSVKLL EYMAHIAPEV VGQVAIPMTG MINGNQAIRE FIQGQGGWEN LES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards