About Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (MAGI3) is a protein
from Homo sapiens identified by UniProt accession
Q5TCQ9, 1481 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 |
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| UniProt accession | Q5TCQ9 |
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| Gene | MAGI3 |
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| Organism | Homo sapiens |
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| Length | 1481 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- autoimmune thyroid disease · score 0.24
- neuroinflammatory disorder · score 0.22
- rheumatoid arthritis · score 0.21
- Crohn's disease · score 0.20
- PHF-tau measurement · score 0.18
- hypothyroidism · score 0.18
- bone density · score 0.16
- urate measurement · score 0.16
- parental longevity · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TCQ9-F1 | alphafold | PREDICTED | 59.21 | — |
Amino-acid sequence (1481 residues)
MSKTLKKKKH WLSKVQECAV SWAGPPGDFG AEIRGGAERG EFPYLGRLRE EPGGGTCCVV SGKAPSPGDV LLEVNGTPVS GLTNRDTLAV IRHFREPIRL KTVKPGKVIN KDLRHYLSLQ FQKGSIDHKL QQVIRDNLYL RTIPCTTRAP RDGEVPGVDY NFISVEQFKA LEESGALLES GTYDGNFYGT PKPPAEPSPF QPDPVDQVLF DNEFDAESQR KRTTSVSKME RMDSSLPEEE EDEDKEAING SGNAENRERH SESSDWMKTV PSYNQTNSSM DFRNYMMRDE TLEPLPKNWE MAYTDTGMIY FIDHNTKTTT WLDPRLCKKA KAPEDCEDGE LPYGWEKIED PQYGTYYVDH LNQKTQFENP VEEAKRKKQL GQVEIGSSKP DMEKSHFTRD PSQLKGVLVR ASLKKSTMGF GFTIIGGDRP DEFLQVKNVL KDGPAAQDGK IAPGDVIVDI NGNCVLGHTH ADVVQMFQLV PVNQYVNLTL CRGYPLPDDS EDPVVDIVAA TPVINGQSLT KGETCMNPQD FKPGAMVLEQ NGKSGHTLTG DGLNGPSDAS EQRVSMASSG SSQPELVTIP LIKGPKGFGF AIADSPTGQK VKMILDSQWC QGLQKGDIIK EIYHQNVQNL THLQVVEVLK QFPVGADVPL LILRGGPPSP TKTAKMKTDK KENAGSLEAI NEPIPQPMPF PPSIIRSGSP KLDPSEVYLK SKTLYEDKPP NTKDLDVFLR KQESGFGFRV LGGDGPDQSI YIGAIIPLGA AEKDGRLRAA DELMCIDGIP VKGKSHKQVL DLMTTAARNG HVLLTVRRKI FYGEKQPEDD SSQAFISTQN GSPRLNRAEV PARPAPQEPY DVVLQRKENE GFGFVILTSK NKPPPGVIPH KIGRVIEGSP ADRCGKLKVG DHISAVNGQS IVELSHDNIV QLIKDAGVTV TLTVIAEEEH HGPPSGTNSA RQSPALQHRP MGQSQANHIP GDRSALEGEI GKDVSTSYRH SWSDHKHLAQ PDTAVISVVG SRHNQNLGCY PVELERGPRG FGFSLRGGKE YNMGLFILRL AEDGPAIKDG RIHVGDQIVE INGEPTQGIT HTRAIELIQA GGNKVLLLLR PGTGLIPDHG DWDINNPSSS NVIYDEQSPL PPSSHFASIF EESHVPVIEE SLRVQICEKA EELKDIVPEK KSTLNENQPE IKHQSLLQKN VSKRDPPSSH GHSNKKNLLK VENGVTRRGR SVSPKKPASQ HSEEHLDKIP SPLKNNPKRR PRDQSLSPSK GENKSCQVST RAGSGQDQCR KSRGRSASPK KQQKIEGSKA PSNAEAKLLE GKSRRIAGYT GSNAEQIPDG KEKSDVIRKD AKQNQLEKSR TRSPEKKIKR MVEKSLPSKM TNKTTSKEVS ENEKGKKVTT GETSSSNDKI GENVQLSEKR LKQEPEEKVV SNKTEDHKGK ELEAADKNKE TGRFKPESSS PVKKTLITPG PWKVPSGNKV TGTIGMAEKR Q
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