Four and a half LIM domains protein 5 (FHL5)

About Four and a half LIM domains protein 5

Four and a half LIM domains protein 5 (FHL5) is a protein from Homo sapiens identified by UniProt accession Q5TD97, 284 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.

Target properties

Protein name	Four and a half LIM domains protein 5
UniProt accession	Q5TD97
Gene	FHL5
Organism	Homo sapiens
Length	284 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (143)

Diseases linked to this target (Open Targets).

migraine disorder · score 0.48
systolic blood pressure · score 0.48
pulse pressure measurement · score 0.46
Headache · score 0.43
diastolic blood pressure · score 0.42
nervous system disease · score 0.30
migraine with aura · score 0.29
Cluster headache · score 0.27
Antimigraine preparation use measurement · score 0.26
hypertension · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TD97-F1	alphafold	PREDICTED	89.77	—

Amino-acid sequence (284 residues)

MTTAHFYCQY CTASLLGKKY VLKDDSPYCV TCYDRVFSNY CEECKKPIES DSKDLCYKDR HWHEGCFKCT KCNHSLVEKP FAAKDERLLC TECYSNECSS KCFHCKRTIM PGSRKMEFKG NYWHETCFVC ENCRQPIGTK PLISKESGNY CVPCFEKEFA HYCNFCKKVI TSGGITFCDQ LWHKECFLCS GCRKDLCEEQ FMSRDDYPFC VDCYNHLYAN KCVACSKPIS GLTGAKFICF QDSQWHSECF NCGKCSVSLV GKGFLTQNKE IFCQKCGSGM DTDI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards