5'-nucleotidase domain-containing protein 1 (NT5DC1)

About 5'-nucleotidase domain-containing protein 1

5'-nucleotidase domain-containing protein 1 (NT5DC1) is a protein from Homo sapiens identified by UniProt accession Q5TFE4, 455 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	5'-nucleotidase domain-containing protein 1
UniProt accession	Q5TFE4
Gene	NT5DC1
Organism	Homo sapiens
Length	455 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

Metaphyseal chondrodysplasia, Schmid type · score 0.55
refractive error · score 0.29
hematocrit · score 0.28
refractive error measurement · score 0.26
alkaline phosphatase measurement · score 0.23
Abnormality of refraction · score 0.23
hemoglobin measurement · score 0.23
Myopia · score 0.23
age-related macular degeneration · score 0.19
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TFE4-F1	alphafold	PREDICTED	88.41	—

Amino-acid sequence (455 residues)

MAQHFSLAAC DVVGFDLDHT LCRYNLPESA PLIYNSFAQF LVKEKGYDKE LLNVTPEDWD FCCKGLALDL EDGNFLKLAN NGTVLRASHG TKMMTPEVLA EAYGKKEWKH FLSDTGMACR SGKYYFYDNY FDLPGALLCA RVVDYLTKLN NGQKTFDFWK DIVAAIQHNY KMSAFKENCG IYFPEIKRDP GRYLHSCPES VKKWLRQLKN AGKILLLITS SHSDYCRLLC EYILGNDFTD LFDIVITNAL KPGFFSHLPS QRPFRTLEND EEQEALPSLD KPGWYSQGNA VHLYELLKKM TGKPEPKVVY FGDSMHSDIF PARHYSNWET VLILEELRGD EGTRSQRPEE SEPLEKKGKY EGPKAKPLNT SSKKWGSFFI DSVLGLENTE DSLVYTWSCK RISTYSTIAI PSIEAIAELP LDYKFTRFSS SNSKTAGYYP NPPLVLSSDE TLISK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards