Transcription factor HES-3 (HES3)

About Transcription factor HES-3

Transcription factor HES-3 (HES3) is a protein from Homo sapiens identified by UniProt accession Q5TGS1, 186 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Transcription factor HES-3
UniProt accession	Q5TGS1
Gene	HES3
Organism	Homo sapiens
Length	186 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
cancer · score 0.06
QT interval · score 0.06
glioblastoma multiforme · score 0.03
triple-negative breast cancer · score 0.03
non-small cell lung carcinoma · score 0.03
rhabdomyosarcoma · score 0.03
pulse pressure measurement · score 0.03
neoplasm · score 0.02
body height · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TGS1-F1	alphafold	PREDICTED	62.93	—

Amino-acid sequence (186 residues)

MEKKRRARIN VSLEQLKSLL EKHYSHQIRK RKLEKADILE LSVKYMRSLQ NSLQGLWPVP RGAEQPSGFR SCLPGVSQLL RRGDEVGSGL RCPLVPESAA GSTMDSAGLG QEAPALFRPC TPAVWAPAPA AGGPRSPPPL LLLPESLPGS SASVPPPQPA SSRCAESPGL GLRVWRPWGS PGDDLN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards