Translocator protein 2 (TSPO2)

About Translocator protein 2

Translocator protein 2 (TSPO2) is a protein from Homo sapiens identified by UniProt accession Q5TGU0, 170 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Translocator protein 2
UniProt accession	Q5TGU0
Gene	TSPO2
Organism	Homo sapiens
Length	170 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

esophageal carcinoma · score 0.11
type 2 diabetes mellitus · score 0.10
gastric carcinoma · score 0.09
Blackfan-Diamond anemia · score 0.08
alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
Pyruvate kinase hyperactivity · score 0.07
primary familial polycythemia due to EPO receptor mutation · score 0.06
hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.06
beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TGU0-F1	alphafold	PREDICTED	68.18	—

Amino-acid sequence (170 residues)

MRLQGAIFVL LPHLGPILVW LFTRDHMSGW CEGPRMLSWC PFYKVLLLVQ TAIYSVVGYA SYLVWKDLGG GLGWPLALPL GLYAVQLTIS WTVLVLFFTV HNPGLALLHL LLLYGLVVST ALIWHPINKL AALLLLPYLA WLTVTSALTY HLWRDSLCPV HQPQPTEKSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards