About O(6)-methylguanine-induced apoptosis 2
O(6)-methylguanine-induced apoptosis 2 (STPG1) is a protein
from Homo sapiens identified by UniProt accession
Q5TH74, 334 residues long.
MolForge cross-references it against 0 known binders and
11 disease associations.
Target properties
| Protein name | O(6)-methylguanine-induced apoptosis 2 |
|---|
| UniProt accession | Q5TH74 |
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| Gene | STPG1 |
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| Organism | Homo sapiens |
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| Length | 334 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (11)
Diseases linked to this target (Open Targets).
- van der Woude syndrome · score 0.15
- hair colour measurement · score 0.14
- cutaneous melanoma · score 0.13
- hair color · score 0.13
- metabolite measurement · score 0.05
- myeloid sarcoma · score 0.00
- neoplasm · score 0.00
- Sepsis · score 0.00
- Uveal melanoma · score 0.00
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5TH74-F1 | alphafold | PREDICTED | 63.78 | — |
Amino-acid sequence (334 residues)
MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK GFNSQAKRFP HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR LDTIISKYPA ANAYTIPSDF ISKRDFSNSC SSMFQLPSFM KALKFETPAP NYYNASVSCC KQRNNVCTRA GFMSKTQRGS FAFADKGPPP GHYDINESLV KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP KKTLFPKNPI LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL
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